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    bcc-1 SAM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178008, updated on 23-Nov-2023

    Summary

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    Gene symbol
    bcc-1
    Gene description
    SAM domain-containing protein
    Primary source
    WormBase:WBGene00000246
    Locus tag
    CELE_M7.3
    See related
    AllianceGenome:WB:WBGene00000246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in cytoplasm. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in diffuse cystic renal dysplasia. Orthologous to human BICC1 (BicC family RNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (11086074..11092552, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Kinesin light chain Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene N-acetyltransferase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oligoarray comparative genomic hybridization-mediated mapping of suppressor mutations generated in a deletion-biased mutagenesis screen. Jones MR, et al. G3 (Bethesda), 2012 Jun. PMID 22690375, Free PMC Article
    2. The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans. Jones MR, et al. Genesis, 2013 Aug. PMID 23733356, Free PMC Article
    3. GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans. Eckmann CR, et al. Dev Cell, 2002 Nov. PMID 12431376
    4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SAM domain-containing protein
    NP_502067.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11086074..11092552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069666.6 → NP_502067.2  SAM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502067.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21593
      Conserved Domains (2) summary
      smart00454
      Location:571 → 636
      SAM; Sterile alpha motif
      cd02394
      Location:105 → 171
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    Nucleotide Protein
    Heading Accession and Version

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