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    Mast2 microtubule associated serine/threonine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 17776, updated on 24-Apr-2022

    Summary

    Official Symbol
    Mast2provided by MGI
    Official Full Name
    microtubule associated serine/threonine kinase 2provided by MGI
    Primary source
    MGI:MGI:894676
    See related
    Ensembl:ENSMUSG00000003810 AllianceGenome:MGI:894676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtssk; MAST205
    Summary
    Enables several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Involved in protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Located in microtubule cytoskeleton. Is expressed in central nervous system; lung epithelium; retina; and testis. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.2), CNS E18 (RPKM 23.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mast2 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116163957..116321420, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116306760..116464223, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (115979367..116136788, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene LLP homolog, pseudogene 1 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene predicted gene, 52760 Neighboring gene IAP promoted placental gene Neighboring gene transmembrane protein 69

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0807

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatid differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated serine/threonine-protein kinase 2
    Names
    microtubule associated testis specific serine/threonine protein kinase
    NP_001036208.1
    NP_001355990.1
    NP_001355991.1
    NP_032667.2
    XP_006502897.1
    XP_006502898.1
    XP_006502899.1
    XP_006502902.1
    XP_030109157.1
    XP_036019689.1
    XP_036019690.1
    XP_036019691.1
    XP_036019692.1
    XP_036019693.1
    XP_036019694.1
    XP_036019695.1
    XP_036019696.1
    XP_036019697.1
    XP_036019698.1
    XP_036019699.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042743.2NP_001036208.1  microtubule-associated serine/threonine-protein kinase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC060703, BY597795, CB246117, CJ182836
      Consensus CDS
      CCDS38850.1
      UniProtKB/Swiss-Prot
      Q60592
      UniProtKB/TrEMBL
      E9Q1Q1
      Related
      ENSMUSP00000102095.2, ENSMUST00000106486.8
      Conserved Domains (4) summary
      smart00220
      Location:520793
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11101191
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202483
      DUF1908; Domain of unknown function (DUF1908)
    2. NM_001369061.1NP_001355990.1  microtubule-associated serine/threonine-protein kinase 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL627394, AL669953, AL670603
      Conserved Domains (3) summary
      cd00992
      Location:11101191
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:519798
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202483
      DUF1908; Domain of unknown function (DUF1908)
    3. NM_001369062.1NP_001355991.1  microtubule-associated serine/threonine-protein kinase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627394, AL669953, AL670603
      Conserved Domains (3) summary
      cd00992
      Location:11031184
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:512791
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202476
      DUF1908; Domain of unknown function (DUF1908)
    4. NM_008641.3NP_032667.2  microtubule-associated serine/threonine-protein kinase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BC060703, BU055783, BU610780, BU701350, BU706282, BY597795, CB246117, CF743521, CJ182836, CK633885, CN696803
      Consensus CDS
      CCDS38849.1
      UniProtKB/Swiss-Prot
      Q60592
      UniProtKB/TrEMBL
      E9QLW6
      Related
      ENSMUSP00000102094.2, ENSMUST00000106485.8
      Conserved Domains (4) summary
      smart00220
      Location:513786
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:11031184
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:512791
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:202476
      DUF1908; Domain of unknown function (DUF1908)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116163957..116321420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502836.5XP_006502899.1  microtubule-associated serine/threonine-protein kinase 2 isoform X5

      Conserved Domains (3) summary
      cd00992
      Location:9591040
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58332
      DUF1908; Domain of unknown function (DUF1908)
    2. XM_006502835.5XP_006502898.1  microtubule-associated serine/threonine-protein kinase 2 isoform X4

      Conserved Domains (3) summary
      cd00992
      Location:9661047
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:375654
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58339
      DUF1908; Domain of unknown function (DUF1908)
    3. XM_030253297.2XP_030109157.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    4. XM_006502834.3XP_006502897.1  microtubule-associated serine/threonine-protein kinase 2 isoform X1

      Related
      ENSMUSP00000159199.2, ENSMUST00000239177.2
      Conserved Domains (3) summary
      cd00992
      Location:10241105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:433712
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116397
      DUF1908; Domain of unknown function (DUF1908)
    5. XM_036163803.1XP_036019696.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    6. XM_036163800.1XP_036019693.1  microtubule-associated serine/threonine-protein kinase 2 isoform X8

      Conserved Domains (3) summary
      cd00992
      Location:9521033
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:361640
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51325
      DUF1908; Domain of unknown function (DUF1908)
    7. XM_036163797.1XP_036019690.1  microtubule-associated serine/threonine-protein kinase 2 isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:10171098
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:426705
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116390
      DUF1908; Domain of unknown function (DUF1908)
    8. XM_036163796.1XP_036019689.1  microtubule-associated serine/threonine-protein kinase 2 isoform X2

      Conserved Domains (3) summary
      cd00992
      Location:10171098
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:426705
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:116390
      DUF1908; Domain of unknown function (DUF1908)
    9. XM_036163802.1XP_036019695.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    10. XM_036163798.1XP_036019691.1  microtubule-associated serine/threonine-protein kinase 2 isoform X6

      Conserved Domains (3) summary
      cd00992
      Location:9591040
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51332
      DUF1908; Domain of unknown function (DUF1908)
    11. XM_036163806.1XP_036019699.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    12. XM_036163805.1XP_036019698.1  microtubule-associated serine/threonine-protein kinase 2 isoform X11

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    13. XM_036163799.1XP_036019692.1  microtubule-associated serine/threonine-protein kinase 2 isoform X7

      Conserved Domains (3) summary
      cd00992
      Location:9591040
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51332
      DUF1908; Domain of unknown function (DUF1908)
    14. XM_036163801.1XP_036019694.1  microtubule-associated serine/threonine-protein kinase 2 isoform X9

      Related
      ENSMUSP00000159270.2, ENSMUST00000239239.2
      Conserved Domains (3) summary
      cd00992
      Location:9521033
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:361640
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:51325
      DUF1908; Domain of unknown function (DUF1908)
    15. XM_036163804.1XP_036019697.1  microtubule-associated serine/threonine-protein kinase 2 isoform X10

      Conserved Domains (3) summary
      cd00992
      Location:810891
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:219498
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:1183
      DUF1908; Domain of unknown function (DUF1908)
    16. XM_006502839.1XP_006502902.1  microtubule-associated serine/threonine-protein kinase 2 isoform X12

      Conserved Domains (3) summary
      smart00133
      Location:231
      S_TK_X; Extension to Ser/Thr-type protein kinases
      cd00992
      Location:317398
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02163
      Location:347455
      Peptidase_M50; Peptidase family M50