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    Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase [ Mus musculus (house mouse) ]

    Gene ID: 17768, updated on 9-Sep-2018

    Summary

    Official Symbol
    Mthfd2provided by MGI
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolaseprovided by MGI
    Primary source
    MGI:MGI:1338850
    See related
    Ensembl:ENSMUSG00000005667 Vega:OTTMUSG00000023127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NMDMC; AW558851
    Expression
    Broad expression in liver E14 (RPKM 25.7), liver E14.5 (RPKM 21.2) and 17 other tissues See more
    Orthologs

    Genomic context

    See Mthfd2 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (83305704..83326035, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (83255698..83267598, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 15624 Neighboring gene dynactin 1 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene MOB kinase activator 1A Neighboring gene bolA-like 3 (E. coli)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    methenyltetrahydrofolate cyclohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylenetetrahydrofolate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylenetetrahydrofolate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylenetetrahydrofolate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tetrahydrofolate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
    NP_032664.1
    XP_006505760.1
    XP_011239547.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008638.2NP_032664.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032664.1

      Status: VALIDATED

      Source sequence(s)
      AK159680, BY068806, DV651355
      Consensus CDS
      CCDS20277.1
      UniProtKB/Swiss-Prot
      P18155
      Related
      ENSMUSP00000005810.6, OTTMUSP00000026807, ENSMUST00000005810.8, OTTMUST00000055880
      Conserved Domains (3) summary
      cd01080
      Location:150329
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:39333
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:39155
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      83305704..83326035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505697.3XP_006505760.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform X2

      Conserved Domains (3) summary
      cd01080
      Location:131310
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:20314
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:20136
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    2. XM_011241245.2XP_011239547.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform X1

      Conserved Domains (3) summary
      cd01080
      Location:153332
      NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:42336
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:42158
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
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