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    Mtf1 metal response element binding transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17764, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mtf1provided by MGI
    Official Full Name
    metal response element binding transcription factor 1provided by MGI
    Primary source
    MGI:MGI:101786
    See related
    Ensembl:ENSMUSG00000028890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thy; MTF-1; Thyls
    Expression
    Ubiquitous expression in testis adult (RPKM 20.4), colon adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtf1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.91 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124696342..124743593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124802549..124849800)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (124479793..124527044)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene microRNA 698 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256 Neighboring gene mannosidase, endo-alpha-like Neighboring gene yrdC domain containing (E.coli) Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    thymic lymphoma susceptibility
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metal regulatory transcription factor 1
    Names
    MRE-binding transcription factor
    metalloregulatory transcription factor
    transcription factor MTF-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008636.4NP_032662.3  metal regulatory transcription factor 1

      See identical proteins and their annotated locations for NP_032662.3

      Status: VALIDATED

      Source sequence(s)
      AK021268, AK030284, AK030868, AK036233, AK150295, CF354134, CK380917, DV658365
      Consensus CDS
      CCDS18627.1
      UniProtKB/Swiss-Prot
      Q07243
      UniProtKB/TrEMBL
      Q8BSY2
      Related
      ENSMUSP00000030723.3, ENSMUST00000030723.3
      Conserved Domains (3) summary
      COG5048
      Location:92308
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:244270
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124696342..124743593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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