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    Mtf1 metal response element binding transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17764, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mtf1provided by MGI
    Official Full Name
    metal response element binding transcription factor 1provided by MGI
    Primary source
    MGI:MGI:101786
    See related
    Ensembl:ENSMUSG00000028890 AllianceGenome:MGI:101786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTF-1; Thyls
    Summary
    Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Involved in DNA-templated transcription and cellular response to zinc ion. Acts upstream of or within positive regulation of transcription by RNA polymerase II; response to cadmium ion; and response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.4), colon adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mtf1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.91 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124696342..124743593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124802549..124849800)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene STARR-positive B cell enhancer ABC_E4664 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:124430874-124431061 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene microRNA 698 Neighboring gene STARR-positive B cell enhancer ABC_E7986 Neighboring gene STARR-seq mESC enhancer starr_11345 Neighboring gene RIKEN cDNA 1110065P20 gene Neighboring gene predicted gene, 54256 Neighboring gene mannosidase, endo-alpha-like Neighboring gene yrdC domain containing (E.coli) Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    thymic lymphoma susceptibility
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metal regulatory transcription factor 1
    Names
    MRE-binding transcription factor
    metalloregulatory transcription factor
    transcription factor MTF-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008636.4NP_032662.3  metal regulatory transcription factor 1

      See identical proteins and their annotated locations for NP_032662.3

      Status: VALIDATED

      Source sequence(s)
      AK021268, AK030284, AK030868, AK036233, AK150295, CF354134, CK380917, DV658365
      Consensus CDS
      CCDS18627.1
      UniProtKB/Swiss-Prot
      Q07243, Q9JJW8
      UniProtKB/TrEMBL
      Q8BSY2
      Related
      ENSMUSP00000030723.3, ENSMUST00000030723.3
      Conserved Domains (3) summary
      COG5048
      Location:92308
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:244270
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124696342..124743593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)