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    Map4 microtubule-associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 17758, updated on 23-Jun-2021

    Summary

    Official Symbol
    Map4provided by MGI
    Official Full Name
    microtubule-associated protein 4provided by MGI
    Primary source
    MGI:MGI:97178
    See related
    Ensembl:ENSMUSG00000032479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mta; MAP-4; Mtap4; Mtap-4; AA407148
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 29.3), frontal lobe adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Map4 in Genome Data Viewer
    Location:
    9 F2; 9 59.83 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109758909..109913022)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109929841..110083954)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109834278..109986451)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089 Neighboring gene predicted gene 4644 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein 4
    Names
    MAP 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205330.1NP_001192259.1  microtubule-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001192259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
      Source sequence(s)
      AC161246
      Consensus CDS
      CCDS57704.1
      UniProtKB/Swiss-Prot
      P27546
      Related
      ENSMUSP00000035055.11, ENSMUST00000035055.15
      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_001205331.1NP_001192260.1  microtubule-associated protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001192260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161246, AK046825
      Consensus CDS
      CCDS57703.1
      UniProtKB/TrEMBL
      Q78TF3
      Related
      ENSMUSP00000131660.3, ENSMUST00000169851.8
    3. NM_001205332.1NP_001192261.1  microtubule-associated protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001192261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161246, BC050893
      UniProtKB/Swiss-Prot
      P27546
      Conserved Domains (1) summary
      pfam00418
      Location:927956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. NM_001311163.1NP_001298092.1  microtubule-associated protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 5, which is shorter than and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK146790, BB526067, BC042645, BY125595
      Consensus CDS
      CCDS81082.1
      UniProtKB/Swiss-Prot
      P27546
      UniProtKB/TrEMBL
      E9PZ43
      Related
      ENSMUSP00000131285.4, ENSMUST00000164930.8
      Conserved Domains (1) summary
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. NM_001311164.1NP_001298093.1  microtubule-associated protein 4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 6, which is shorter than and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK166558, BB526067, BC042645, BY125595
      Consensus CDS
      CCDS81083.1
      UniProtKB/Swiss-Prot
      P27546
      UniProtKB/TrEMBL
      A0A0G2JDN7
      Related
      ENSMUSP00000142439.2, ENSMUST00000199498.5
      Conserved Domains (1) summary
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    6. NM_008633.4NP_032659.2  microtubule-associated protein 4 isoform 2

      See identical proteins and their annotated locations for NP_032659.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is the same length as isoform 1.
      Source sequence(s)
      AC161246, BC044654
      UniProtKB/Swiss-Prot
      P27546
      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      109758909..109913022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244102.1XP_030099962.1  microtubule-associated protein 4 isoform X9

      Conserved Domains (3) summary
      PHA03247
      Location:532828
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:6871042
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:891920
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. XM_036154653.1XP_036010546.1  microtubule-associated protein 4 isoform X11

      Conserved Domains (2) summary
      PHA03307
      Location:545884
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:891921
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. XM_036154656.1XP_036010549.1  microtubule-associated protein 4 isoform X14

      Conserved Domains (2) summary
      pfam05109
      Location:5961004
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. XM_036154660.1XP_036010553.1  microtubule-associated protein 4 isoform X18

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. XM_036154661.1XP_036010554.1  microtubule-associated protein 4 isoform X19

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    6. XM_036154662.1XP_036010555.1  microtubule-associated protein 4 isoform X20

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    7. XM_036154663.1XP_036010556.1  microtubule-associated protein 4 isoform X25

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    8. XM_036154652.1XP_036010545.1  microtubule-associated protein 4 isoform X10

      Conserved Domains (2) summary
      PHA03307
      Location:545884
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:891921
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    9. XM_036154657.1XP_036010550.1  microtubule-associated protein 4 isoform X15

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    10. XM_036154658.1XP_036010551.1  microtubule-associated protein 4 isoform X16

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    11. XM_036154659.1XP_036010552.1  microtubule-associated protein 4 isoform X17

      Conserved Domains (2) summary
      PHA03307
      Location:545849
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00418
      Location:853883
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    12. XM_006511955.3XP_006512018.1  microtubule-associated protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006512018.1

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    13. XM_036154649.1XP_036010542.1  microtubule-associated protein 4 isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    14. XM_036154648.1XP_036010541.1  microtubule-associated protein 4 isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    15. XM_036154645.1XP_036010538.1  microtubule-associated protein 4 isoform X2

      Related
      ENSMUSP00000132662.4, ENSMUST00000165876.8
      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:965995
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    16. XM_036154647.1XP_036010540.1  microtubule-associated protein 4 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:965995
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    17. XM_036154655.1XP_036010548.1  microtubule-associated protein 4 isoform X13

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    18. XM_036154646.1XP_036010539.1  microtubule-associated protein 4 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:965995
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    19. XM_036154654.1XP_036010547.1  microtubule-associated protein 4 isoform X12

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    20. XM_036154650.1XP_036010543.1  microtubule-associated protein 4 isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927957
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    21. XM_030244101.2XP_030099961.1  microtubule-associated protein 4 isoform X8

      Conserved Domains (2) summary
      PHA03247
      Location:593903
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:927956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    22. XM_006511960.4XP_006512023.1  microtubule-associated protein 4 isoform X21

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:812841
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    23. XM_017313175.3XP_017168664.1  microtubule-associated protein 4 isoform X23

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:812841
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    24. XM_017313176.3XP_017168665.1  microtubule-associated protein 4 isoform X24

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:812841
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    25. XM_036154664.1XP_036010557.1  microtubule-associated protein 4 isoform X26

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:812842
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    26. XM_036154665.1XP_036010558.1  microtubule-associated protein 4 isoform X27

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:774804
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    27. XM_017313178.3XP_017168667.1  microtubule-associated protein 4 isoform X29

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    28. XM_036154667.1XP_036010560.1  microtubule-associated protein 4 isoform X30

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:774804
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    29. XM_006511962.5XP_006512025.1  microtubule-associated protein 4 isoform X31

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    30. XM_006511964.4XP_006512027.1  microtubule-associated protein 4 isoform X32

      Conserved Domains (2) summary
      pfam05109
      Location:528889
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:738767
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    31. XM_017313179.2XP_017168668.1  microtubule-associated protein 4 isoform X34

      Conserved Domains (2) summary
      pfam05109
      Location:528888
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:738767
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    32. XM_017313180.2XP_017168669.1  microtubule-associated protein 4 isoform X35

      Conserved Domains (2) summary
      pfam05109
      Location:528871
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:738767
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    33. XM_017313181.2XP_017168670.1  microtubule-associated protein 4 isoform X36

      Conserved Domains (2) summary
      pfam05109
      Location:499851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    34. XM_017313183.2XP_017168672.1  microtubule-associated protein 4 isoform X38

      Conserved Domains (2) summary
      pfam05109
      Location:499851
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    35. XM_017313185.3XP_017168674.1  microtubule-associated protein 4 isoform X40

      Conserved Domains (2) summary
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam17823
      Location:532687
      DUF5585; Family of unknown function (DUF5585)
    36. XM_017313184.2XP_017168673.1  microtubule-associated protein 4 isoform X39

      Conserved Domains (2) summary
      pfam05109
      Location:499850
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    37. XM_017313186.2XP_017168675.1  microtubule-associated protein 4 isoform X41

      Conserved Domains (2) summary
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      pfam17823
      Location:532687
      DUF5585; Family of unknown function (DUF5585)
    38. XM_036154669.1XP_036010562.1  microtubule-associated protein 4 isoform X42

      Conserved Domains (2) summary
      pfam05109
      Location:499820
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700730
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    39. XM_017313187.2XP_017168676.1  microtubule-associated protein 4 isoform X43

      Conserved Domains (2) summary
      pfam05109
      Location:499819
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    40. XM_017313188.2XP_017168677.1  microtubule-associated protein 4 isoform X44

      Conserved Domains (2) summary
      pfam05109
      Location:499819
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    41. XM_017313174.3XP_017168663.1  microtubule-associated protein 4 isoform X22

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:812841
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    42. XM_036154668.1XP_036010561.1  microtubule-associated protein 4 isoform X33

      Conserved Domains (2) summary
      pfam05109
      Location:528888
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:738768
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    43. XM_017313182.3XP_017168671.1  microtubule-associated protein 4 isoform X37

      Conserved Domains (2) summary
      pfam05109
      Location:499850
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00418
      Location:700729
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    44. XM_017313177.3XP_017168666.1  microtubule-associated protein 4 isoform X28

      Conserved Domains (2) summary
      PHA03247
      Location:516750
      PHA03247; large tegument protein UL36; Provisional
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
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