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    Map4 microtubule-associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 17758, updated on 5-Aug-2018

    Summary

    Official Symbol
    Map4provided by MGI
    Official Full Name
    microtubule-associated protein 4provided by MGI
    Primary source
    MGI:MGI:97178
    See related
    Ensembl:ENSMUSG00000032479 Vega:OTTMUSG00000035845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAP-4; Mtap4; Mtap-4; AA407148
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 29.3), frontal lobe adult (RPKM 18.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Map4 in Genome Data Viewer
    Location:
    9 F2; 9 59.83 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (109931489..110083954)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (109834278..109986451)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene microRNA 7089 Neighboring gene predicted gene 4644 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 30 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell division ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    establishment of spindle orientation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule sliding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule sliding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    microtubule-associated protein 4
    Names
    MAP 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205330.1NP_001192259.1  microtubule-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001192259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
      Source sequence(s)
      AC161246
      Consensus CDS
      CCDS57704.1
      UniProtKB/Swiss-Prot
      P27546
      Related
      ENSMUSP00000035055.10, OTTMUSP00000050617, ENSMUST00000035055.14, OTTMUST00000091828
      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_001205331.1NP_001192260.1  microtubule-associated protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001192260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161246, AK046825
      Consensus CDS
      CCDS57703.1
      UniProtKB/TrEMBL
      Q78TF3
      Related
      ENSMUSP00000131660.2, OTTMUSP00000069800, ENSMUST00000169851.7, OTTMUST00000130117
    3. NM_001205332.1NP_001192261.1  microtubule-associated protein 4 isoform 4

      See identical proteins and their annotated locations for NP_001192261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161246, BC050893
      UniProtKB/Swiss-Prot
      P27546
      Conserved Domains (1) summary
      pfam00418
      Location:927956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. NM_001311163.1NP_001298092.1  microtubule-associated protein 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 5, which is shorter than and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK146790, BB526067, BC042645, BY125595
      Consensus CDS
      CCDS81082.1
      UniProtKB/Swiss-Prot
      P27546
      UniProtKB/TrEMBL
      E9PZ43
      Related
      ENSMUSP00000131285.3, OTTMUSP00000050620, ENSMUST00000164930.7, OTTMUST00000091831
      Conserved Domains (1) summary
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. NM_001311164.1NP_001298093.1  microtubule-associated protein 4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple coding region differences, including use of an alternate translation initiation site compared to variant 1. It encodes isoform 6, which is shorter than and has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK166558, BB526067, BC042645, BY125595
      Consensus CDS
      CCDS81083.1
      UniProtKB/Swiss-Prot
      P27546
      UniProtKB/TrEMBL
      A0A0G2JDN7
      Related
      ENSMUSP00000142439.1, OTTMUSP00000050621, ENSMUST00000199498.4, OTTMUST00000091832
      Conserved Domains (1) summary
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    6. NM_008633.4NP_032659.2  microtubule-associated protein 4 isoform 2

      See identical proteins and their annotated locations for NP_032659.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is the same length as isoform 1.
      Source sequence(s)
      AC161246, BC044654
      UniProtKB/Swiss-Prot
      P27546
      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      109931489..110083954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511955.2XP_006512018.1  microtubule-associated protein 4 isoform X5

      See identical proteins and their annotated locations for XP_006512018.1

      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. XM_006511967.2XP_006512030.1  microtubule-associated protein 4 isoform X37

      See identical proteins and their annotated locations for XP_006512030.1

      UniProtKB/TrEMBL
      Q78TF3
    3. XM_006511956.2XP_006512019.1  microtubule-associated protein 4 isoform X5

      See identical proteins and their annotated locations for XP_006512019.1

      Conserved Domains (1) summary
      pfam00418
      Location:965994
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    4. XM_011242936.1XP_011241238.1  microtubule-associated protein 4 isoform X6

      Conserved Domains (1) summary
      pfam00418
      Location:927956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    5. XM_017313165.1XP_017168654.1  microtubule-associated protein 4 isoform X7

    6. XM_011242937.1XP_011241239.1  microtubule-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam00418
      Location:927956
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    7. XM_017313166.1XP_017168655.1  microtubule-associated protein 4 isoform X9

    8. XM_017313167.1XP_017168656.1  microtubule-associated protein 4 isoform X10

    9. XM_017313168.1XP_017168657.1  microtubule-associated protein 4 isoform X11

    10. XM_017313170.1XP_017168659.1  microtubule-associated protein 4 isoform X13

    11. XM_017313171.1XP_017168660.1  microtubule-associated protein 4 isoform X14

    12. XM_017313164.1XP_017168653.1  microtubule-associated protein 4 isoform X4

      UniProtKB/Swiss-Prot
      P27546
      Related
      ENSMUSP00000132662.3, OTTMUSP00000050618, ENSMUST00000165876.7, OTTMUST00000091829
    13. XM_017313169.1XP_017168658.1  microtubule-associated protein 4 isoform X12

    14. XM_017313172.1XP_017168661.1  microtubule-associated protein 4 isoform X15

    15. XM_017313173.1XP_017168662.1  microtubule-associated protein 4 isoform X16

    16. XM_011242938.2XP_011241240.1  microtubule-associated protein 4 isoform X36

    17. XM_017313161.1XP_017168650.1  microtubule-associated protein 4 isoform X1

    18. XM_017313162.1XP_017168651.1  microtubule-associated protein 4 isoform X2

    19. XM_017313163.1XP_017168652.1  microtubule-associated protein 4 isoform X3

      Related
      ENSMUSP00000143171.1, OTTMUSP00000050619, ENSMUST00000163190.7, OTTMUST00000091830
    20. XM_006511960.3XP_006512023.1  microtubule-associated protein 4 isoform X17

      Conserved Domains (1) summary
      pfam00418
      Location:812841
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    21. XM_017313183.1XP_017168672.1  microtubule-associated protein 4 isoform X29

    22. XM_017313186.1XP_017168675.1  microtubule-associated protein 4 isoform X32

    23. XM_017313174.1XP_017168663.1  microtubule-associated protein 4 isoform X18

    24. XM_017313177.1XP_017168666.1  microtubule-associated protein 4 isoform X21

    25. XM_017313178.1XP_017168667.1  microtubule-associated protein 4 isoform X22

    26. XM_006511962.3XP_006512025.1  microtubule-associated protein 4 isoform X23

      Conserved Domains (1) summary
      pfam00418
      Location:774803
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    27. XM_006511964.3XP_006512027.1  microtubule-associated protein 4 isoform X24

      Conserved Domains (1) summary
      pfam00418
      Location:738767
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    28. XM_017313179.1XP_017168668.1  microtubule-associated protein 4 isoform X25

    29. XM_017313188.1XP_017168677.1  microtubule-associated protein 4 isoform X34

    30. XM_017313175.1XP_017168664.1  microtubule-associated protein 4 isoform X19

    31. XM_017313176.1XP_017168665.1  microtubule-associated protein 4 isoform X20

    32. XM_017313189.1XP_017168678.1  microtubule-associated protein 4 isoform X35

    33. XM_017313181.1XP_017168670.1  microtubule-associated protein 4 isoform X27

    34. XM_017313184.1XP_017168673.1  microtubule-associated protein 4 isoform X30

    35. XM_017313180.1XP_017168669.1  microtubule-associated protein 4 isoform X26

    36. XM_017313185.1XP_017168674.1  microtubule-associated protein 4 isoform X31

    37. XM_017313182.1XP_017168671.1  microtubule-associated protein 4 isoform X28

    38. XM_017313187.1XP_017168676.1  microtubule-associated protein 4 isoform X33

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