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    Polr2k polymerase (RNA) II (DNA directed) polypeptide K [ Mus musculus (house mouse) ]

    Gene ID: 17749, updated on 8-Jul-2021

    Summary

    Official Symbol
    Polr2kprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Kprovided by MGI
    Primary source
    MGI:MGI:102725
    See related
    Ensembl:ENSMUSG00000045996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Maf; Mt1; RPA; RPB; MafY; Mt1a; RPB1; RPB7; RPB12; ABC10-; RPABC4; RPB7.0; RPB10alpha; ABC10-alpha
    Expression
    Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 19.6) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Polr2k in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (36174156..36177158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (36174010..36177012)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (36103772..36106767)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 22 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene predicted gene, 22979 Neighboring gene sperm associated antigen 1 Neighboring gene predicted gene, 23754 Neighboring gene predicted gene, 41293

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Names
    metallothionein-I gene transcription activator
    NP_001034457.1
    NP_075616.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039368.2NP_001034457.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform a

      See identical proteins and their annotated locations for NP_001034457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK008136, BY646564, CR516049
      Consensus CDS
      CCDS27426.1
      UniProtKB/TrEMBL
      Q8BFX0
      Related
      ENSMUSP00000051968.6, ENSMUST00000057177.7
      Conserved Domains (1) summary
      smart00659
      Location:5699
      RPOLCX; RNA polymerase subunit CX
    2. NM_023127.3NP_075616.2  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b

      See identical proteins and their annotated locations for NP_075616.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK003023, AK008136, BY646564, CR516049
      Consensus CDS
      CCDS56980.1
      UniProtKB/Swiss-Prot
      Q63871
      UniProtKB/TrEMBL
      Q545V5, Q8BFX0
      Related
      ENSMUSP00000136975.2, ENSMUST00000180159.8
      Conserved Domains (1) summary
      smart00659
      Location:1558
      RPOLCX; RNA polymerase subunit CX

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      36174156..36177158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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