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    Polr2k polymerase (RNA) II (DNA directed) polypeptide K [ Mus musculus (house mouse) ]

    Gene ID: 17749, updated on 9-Sep-2018

    Summary

    Official Symbol
    Polr2kprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Kprovided by MGI
    Primary source
    MGI:MGI:102725
    See related
    Ensembl:ENSMUSG00000045996 Vega:OTTMUSG00000042372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MafY; Mt1a; RPB12; RPABC4; RPB7.0; RPB10alpha; ABC10-alpha
    Expression
    Broad expression in CNS E11.5 (RPKM 21.0), liver E14 (RPKM 19.6) and 17 other tissues See more
    Orthologs

    Genomic context

    See Polr2k in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (36174010..36177012)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (36103772..36106767)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signalling 22 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene Neighboring gene F-box protein 43 Neighboring gene sperm associated antigen 1 Neighboring gene predicted gene, 41293 Neighboring gene microRNA 8097 Neighboring gene ring finger protein 19A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC4
    Names
    metallothionein-I gene transcription activator
    NP_001034457.1
    NP_075616.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039368.2NP_001034457.1  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform a

      See identical proteins and their annotated locations for NP_001034457.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK008136, BY646564, CR516049
      Consensus CDS
      CCDS27426.1
      UniProtKB/TrEMBL
      Q8BFX0
      Related
      ENSMUSP00000051968.5, OTTMUSP00000062563, ENSMUST00000057177.6, OTTMUST00000111664
      Conserved Domains (1) summary
      smart00659
      Location:5699
      RPOLCX; RNA polymerase subunit CX
    2. NM_023127.3NP_075616.2  DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform b

      See identical proteins and their annotated locations for NP_075616.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK003023, AK008136, BY646564, CR516049
      Consensus CDS
      CCDS56980.1
      UniProtKB/Swiss-Prot
      Q63871
      UniProtKB/TrEMBL
      Q545V5, Q8BFX0
      Related
      ENSMUSP00000136975.1, OTTMUSP00000062562, ENSMUST00000180159.7, OTTMUST00000111663
      Conserved Domains (1) summary
      smart00659
      Location:1558
      RPOLCX; RNA polymerase subunit CX

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      36174010..36177012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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