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    jmjd-1.2 JmjC domain-containing protein;Lysine-specific demethylase 7 homolog [ Caenorhabditis elegans ]

    Gene ID: 177232, updated on 2-Nov-2024

    Summary

    Official Symbol
    jmjd-1.2
    Official Full Name
    JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
    Primary source
    WormBase:WBGene00017920
    Locus tag
    CELE_F29B9.2
    See related
    AllianceGenome:WB:WBGene00017920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Is expressed in several structures, including germ cell; hypodermis; intestine; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma and syndromic X-linked intellectual disability Siderius type. Orthologous to several human genes including KDM7A (lysine demethylase 7A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See jmjd-1.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (4660991..4665212)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mitochondrial Ribosomal Protein, Small Neighboring gene Cytochrome c oxidase polypeptide VIIc Neighboring gene Protein-lysine N-methyltransferase CELE_F29B9.1 Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K27me2/H3K27me3 demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K9 demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K9 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    JmjC domain-containing protein;Lysine-specific demethylase 7 homolog
    NP_001294381.1
    • Confirmed by transcript evidence
    NP_500610.1
    • Confirmed by transcript evidence
    NP_500611.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      4660991..4665212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068209.7NP_500610.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BI67, Q9GYI0
      Conserved Domains (2) summary
      cd15517
      Location:211287
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      cl21464
      Location:495595
      cupin_like; Conserved domain found in cupin and related proteins
    2. NM_068210.5NP_500611.1  Lysine-specific demethylase 7 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GYI0
      Conserved Domains (2) summary
      cd15517
      Location:198274
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      cl21464
      Location:482582
      cupin_like; Conserved domain found in cupin and related proteins
    3. NM_001307452.3NP_001294381.1  JmjC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294381.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB84
      Conserved Domains (3) summary
      cd15517
      Location:230306
      PHD_TCF19_like; PHD finger found in Transcription factor 19 (TCF-19), Lysine-specific demethylase KDM5A and KDM5B, and other similar proteins
      pfam17811
      Location:619705
      JHD; Jumonji helical domain
      cl21464
      Location:514614
      cupin_like; Conserved domain found in cupin and related proteins