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    Msl3 MSL complex subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 17692, updated on 5-Sep-2021

    Summary

    Official Symbol
    Msl3provided by MGI
    Official Full Name
    MSL complex subunit 3provided by MGI
    Primary source
    MGI:MGI:1341851
    See related
    Ensembl:ENSMUSG00000031358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl; Msl31; Msl3l1; AU018931
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.1), placenta adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Msl3 in Genome Data Viewer
    Location:
    X; X F5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (167434263..167457347, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (168651267..168674354, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (165092049..165111834, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene predicted pseudogene 7209 Neighboring gene predicted gene, 39550 Neighboring gene Rho GTPase activating protein 6 Neighboring gene amelogenin, X-linked Neighboring gene holocytochrome c synthetase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity (H4-K16 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-K16 acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    male-specific lethal 3 homolog
    Names
    male-specific lethal-3 homolog 1
    male-specific lethal-3 protein-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370791.1NP_001357720.1  male-specific lethal 3 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Consensus CDS
      CCDS90775.1
      Related
      ENSMUSP00000033725.10, ENSMUST00000033725.16
      Conserved Domains (3) summary
      cd18983
      Location:1581
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:176510
      MRG
      pfam12258
      Location:313412
      Microcephalin; Microcephalin protein
    2. NM_001370792.1NP_001357721.1  male-specific lethal 3 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      cd18983
      Location:1581
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:175509
      MRG
      pfam12258
      Location:312411
      Microcephalin; Microcephalin protein
    3. NM_001370793.1NP_001357722.1  male-specific lethal 3 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:154488
      MRG
      pfam12258
      Location:291390
      Microcephalin; Microcephalin protein
      cl28914
      Location:1259
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    4. NM_001370794.1NP_001357723.1  male-specific lethal 3 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      cd18983
      Location:1581
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:175499
      MRG
      pfam12258
      Location:312411
      Microcephalin; Microcephalin protein
    5. NM_001370795.1NP_001357724.1  male-specific lethal 3 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:116450
      MRG
      pfam12258
      Location:253352
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    6. NM_001370796.1NP_001357725.1  male-specific lethal 3 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:117441
      MRG
      pfam12258
      Location:254353
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    7. NM_001370797.1NP_001357726.1  male-specific lethal 3 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:116440
      MRG
      pfam12258
      Location:253352
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    8. NM_001370798.1NP_001357727.1  male-specific lethal 3 homolog isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:120426
      MRG
      pfam12258
      Location:229328
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    9. NM_001370799.1NP_001357728.1  male-specific lethal 3 homolog isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Conserved Domains (3) summary
      pfam05712
      Location:117241
      MRG
      pfam12258
      Location:254353
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    10. NM_010832.6NP_034962.2  male-specific lethal 3 homolog isoform 5

      See identical proteins and their annotated locations for NP_034962.2

      Status: VALIDATED

      Source sequence(s)
      AL671489
      Consensus CDS
      CCDS41211.1
      UniProtKB/Swiss-Prot
      Q9WVG9
      Related
      ENSMUSP00000107765.2, ENSMUST00000112137.2
      Conserved Domains (3) summary
      pfam05712
      Location:117451
      MRG
      pfam12258
      Location:254353
      Microcephalin; Microcephalin protein
      cl28914
      Location:322
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      167434263..167457347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318415.3XP_017173904.1  male-specific lethal 3 homolog isoform X1

      Conserved Domains (3) summary
      cd18983
      Location:1581
      CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
      pfam05712
      Location:176500
      MRG
      pfam12258
      Location:313412
      Microcephalin; Microcephalin protein
    2. XM_036161839.1XP_036017732.1  male-specific lethal 3 homolog isoform X4

      Conserved Domains (1) summary
      pfam05712
      Location:5340
      MRG
    3. XM_036161838.1XP_036017731.1  male-specific lethal 3 homolog isoform X3

      Conserved Domains (2) summary
      pfam05712
      Location:144478
      MRG
      cl28914
      Location:1259
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    4. XM_036161837.1XP_036017730.1  male-specific lethal 3 homolog isoform X2

      Conserved Domains (2) summary
      pfam05712
      Location:143487
      MRG
      cl28914
      Location:1259
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
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