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    daf-2 Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase [ Caenorhabditis elegans ]

    Gene ID: 175410, updated on 9-Oct-2021

    Summary

    Gene symbol
    daf-2
    Gene description
    Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase
    Primary source
    WormBase:WBGene00000898
    Locus tag
    CELE_Y55D5A.5
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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    Genomic context

    See daf-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    18
    Sequence:
    Chromosome: III; NC_003281.10 (2994514..3040846, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene N-acylethanolamine-hydrolyzing acid amidase subunit beta Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables PTB domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor substrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to salt IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to salt IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dauer exit IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in heat acclimation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in larval feeding behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dauer entry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_negative_effect protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of development, heterochronic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of eating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of lipid storage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to UV IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of insulin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in spanning component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase
    NP_001299916.1
    • Confirmed by transcript evidence
    NP_001299917.1
    • Confirmed by transcript evidence
    NP_001299918.1
    • Confirmed by transcript evidence
    NP_001299919.1
    • Confirmed by transcript evidence
    NP_001299920.1
    • Confirmed by transcript evidence
    NP_497650.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2994514..3040846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065249.7NP_497650.4  Insulin-like receptor subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497650.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q968Y9
      Conserved Domains (5) summary
      cd05032
      Location:12391522
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:12461520
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:10871173
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:360490
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:512627
      Recep_L_domain; Receptor L domain
    2. NM_001312987.4NP_001299916.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUY1
      Conserved Domains (5) summary
      cd05032
      Location:13211604
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:13281602
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:11691255
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:360490
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:512627
      Recep_L_domain; Receptor L domain
    3. NM_001312988.3NP_001299917.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXA0
      Conserved Domains (5) summary
      cd05032
      Location:11921475
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:11991473
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:10401126
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:313443
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:465580
      Recep_L_domain; Receptor L domain
    4. NM_001312989.3NP_001299918.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARZ1
      Conserved Domains (5) summary
      cd05032
      Location:11631446
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:11701444
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:10111097
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:284414
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:436551
      Recep_L_domain; Receptor L domain
    5. NM_001312990.3NP_001299919.1  Receptor protein-tyrosine kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUA1
      Conserved Domains (3) summary
      cd05032
      Location:429712
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      smart00221
      Location:436710
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:277363
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    6. NM_001312991.3NP_001299920.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARE8
      Conserved Domains (1) summary
      cd05032
      Location:65348
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

    RNA

    1. NR_132448.1 RNA Sequence

      Status: REVIEWED

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