age-1 Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: age-1
Gene description: Phosphatidylinositol 3-kinase age-1
Primary source: WormBase:WBGene00000090
Locus tag: CELE_B0334.8
See related: AllianceGenome:WB:WBGene00000090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; insulin receptor signaling pathway involved in determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Is expressed in hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) and PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (11519328..11527054, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

synaptic PI3K Age-1 is crucial for the behavioral switch caused by learning.
Title: Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.
ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target
Title: ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.
DAF-16 and Delta9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutant
Title: DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
The number of nonredundant gene ontology categories significantly distinguishing age-1 alleles of exceptional longevity increased from sevenfold to greater than ninefold.
Title: Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures.
conclude that extreme age-1 deficiency invokes multiple transcriptional changes.
Title: Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
Studies show that strong mutations to the encoding AGE-1/PI3KCS achieve unprecedented longevity by orchestrating the modulation (predominantly silencing) of multiple signaling pathways.
Title: Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.
Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1.
Title: Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.
Our findings demonstrate a drug-specific interaction between clozapine and the PI3K/insulin-signaling pathway in C. elegans.
Title: Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans.
Suppression of age-1 contributes to exceptional survival.
Title: Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.
In the age-1 allele, which activates an insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, the superoxide dismutase (SOD) and catalase activities increased during normal aging.
Title: Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y62F5A.a (e-PCR)
- UniSTS:323200

Y62F5A.b (e-PCR)
- UniSTS:323201

B0334.8 (e-PCR)
- UniSTS:320443

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to salt	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Phosphatidylinositol 3-kinase age-1

NP_001300488.1

Confirmed by transcript evidence

NP_496462.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11519328..11527054 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064061.6 → NP_496462.2 Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496462.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3ARF0, Q17482, Q94125

Conserved Domains (5) summary

cd08380
Location:420 → 574

C2_PI3K_like; C2 domain present in phosphatidylinositol 3-kinases (PI3Ks)

smart00143
Location:98 → 177

PI3K_p85B; PI3-kinase family, p85-binding domain

smart00144
Location:241 → 360

PI3K_rbd; PI3-kinase family, Ras-binding domain

smart00145
Location:606 → 798

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)

cl21453
Location:793 → 1181

PKc_like; Protein Kinases, catalytic domain
NM_001313559.3 → NP_001300488.1 Phosphatidylinositol 3-kinase age-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARF0

Conserved Domains (1) summary

cl21453
Location:7 → 75

PKc_like; Protein Kinases, catalytic domain