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    Mdh2 malate dehydrogenase 2, NAD (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 17448, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mdh2provided by MGI
    Official Full Name
    malate dehydrogenase 2, NAD (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:97050
    See related
    Ensembl:ENSMUSG00000019179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mo; MDH; Mor; Mor1; Mdh-2; Mor-1
    Expression
    Broad expression in duodenum adult (RPKM 1627.0), heart adult (RPKM 883.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mdh2 in Genome Data Viewer
    Location:
    5 G2; 5 75.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135807503..135819240)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135778649..135790386)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136254519..136266256)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene predicted gene, 30205 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene predicted gene, 22450

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-malate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables L-malate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-malate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malate dehydrogenase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables malate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within malate metabolic process ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    malate dehydrogenase, mitochondrial
    Names
    mitochondrial malate dehydrogenase 2, NAD
    NP_032643.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008617.2NP_032643.2  malate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032643.2

      Status: PROVISIONAL

      Source sequence(s)
      BC023482
      Consensus CDS
      CCDS19746.1
      UniProtKB/Swiss-Prot
      P08249
      Related
      ENSMUSP00000019323.7, ENSMUST00000019323.11
      Conserved Domains (2) summary
      TIGR01772
      Location:26335
      MDH_euk_gproteo; malate dehydrogenase, NAD-dependent
      cd01337
      Location:26334
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135807503..135819240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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