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    Me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Mus musculus (house mouse) ]

    Gene ID: 17436, updated on 23-Jun-2021

    Summary

    Official Symbol
    Me1provided by MGI
    Official Full Name
    malic enzyme 1, NADP(+)-dependent, cytosolicprovided by MGI
    Primary source
    MGI:MGI:97043
    See related
    Ensembl:ENSMUSG00000032418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mod; Mod-; Mod1; Mdh-1; Mod-1; D9Ertd267; D9Ertd267e
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 140.3), mammary gland adult (RPKM 130.2) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Me1 in Genome Data Viewer
    Location:
    9 E3.1; 9 46.58 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86463416..86577967, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86581363..86695914, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (86474970..86589947, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein A Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene predicted gene, 22138 Neighboring gene protease, serine 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91072

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables malic enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malic enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in malate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADP-dependent malic enzyme
    Names
    NADP-ME
    malic enzyme, supernatant
    NP_001185862.1
    NP_032641.2
    XP_011240968.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198933.1NP_001185862.1  NADP-dependent malic enzyme isoform 2

      See identical proteins and their annotated locations for NP_001185862.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon at its 5' UTR and 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK077968, AK163403, AV363687
      Consensus CDS
      CCDS81047.1
      UniProtKB/Swiss-Prot
      P06801
      UniProtKB/TrEMBL
      Q3TQP6
      Related
      ENSMUSP00000140887.2, ENSMUST00000185374.2
      Conserved Domains (3) summary
      cd05312
      Location:250527
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:7531
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:59240
      malic; Malic enzyme, N-terminal domain
    2. NM_008615.2NP_032641.2  NADP-dependent malic enzyme isoform 1

      See identical proteins and their annotated locations for NP_032641.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077968, AV363687, CJ070715
      Consensus CDS
      CCDS23383.1
      UniProtKB/Swiss-Prot
      P06801
      Related
      ENSMUSP00000034989.9, ENSMUST00000034989.15
      Conserved Domains (3) summary
      cd05312
      Location:270547
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:2551
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:79260
      malic; Malic enzyme, N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      86463416..86577967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242666.2XP_011240968.1  NADP-dependent malic enzyme isoform X1

      Conserved Domains (1) summary
      PLN03129
      Location:1476
      PLN03129; NADP-dependent malic enzyme; Provisional
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