Format

Send to:

Choose Destination
    • Showing Current items.

    Afdn afadin, adherens junction formation factor [ Mus musculus (house mouse) ]

    Gene ID: 17356, updated on 23-Jun-2021

    Summary

    Official Symbol
    Afdnprovided by MGI
    Official Full Name
    afadin, adherens junction formation factorprovided by MGI
    Primary source
    MGI:MGI:1314653
    See related
    Ensembl:ENSMUSG00000068036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AF; AF6; I-a; Mll; S-a; Af-6; Gm314; Mllt4; Afadin; I-afadin; S-afadin; 5033403D15Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Afdn in Genome Data Viewer
    Location:
    17; 17 A1- A2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (13980735..14126059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (13760391..13905798)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (13897548..14042801)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41530 Neighboring gene predicted gene, 24867 Neighboring gene t-complex-associated testis expressed 2 Neighboring gene predicted gene 7168 Neighboring gene predicted gene, 33889

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables LIM domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adherens junction maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion mediated by cadherin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of endothelial intestinal barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroepithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mini excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within radial glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within telencephalon development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in tight junction ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    afadin
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
    protein Af-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010806.1NP_034936.1  afadin

      See identical proteins and their annotated locations for NP_034936.1

      Status: VALIDATED

      Source sequence(s)
      AF172447, BI991173, BQ929757, BU611478, CB181965, CF538789, CJ165098, CK637291, CN529812, CN537179, CN538841, CO042367, CO433521
      Consensus CDS
      CCDS49955.1
      UniProtKB/Swiss-Prot
      Q9QZQ1
      Related
      ENSMUSP00000118318.2, ENSMUST00000139666.8
      Conserved Domains (7) summary
      cd01781
      Location:247346
      AF6_RA_repeat2; Ubiquitin domain of AT-6, second repeat
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam03064
      Location:15921678
      U79_P34; HSV U79 / HCMV P34
      pfam15346
      Location:15251668
      ARGLU; Arginine and glutamate-rich 1
      cl00155
      Location:20131
      UBQ; Ubiquitin-like proteins

    RNA

    1. NR_151731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC155253, AC174800, CT030652

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      13980735..14126059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523752.4XP_006523815.1  afadin isoform X1

      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15991698
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14651717
      DUF5401; Family of unknown function (DUF5401)
    2. XM_006523763.4XP_006523826.1  afadin isoform X16

      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15991698
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14651717
      DUF5401; Family of unknown function (DUF5401)
    3. XM_006523755.4XP_006523818.1  afadin isoform X4

      Conserved Domains (7) summary
      PTZ00121
      Location:15091694
      PTZ00121; MAEBL; Provisional
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:16031697
      ARGLU; Arginine and glutamate-rich 1
    4. XM_030249527.2XP_030105387.1  afadin isoform X17

      Conserved Domains (7) summary
      PTZ00121
      Location:15091694
      PTZ00121; MAEBL; Provisional
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:16031697
      ARGLU; Arginine and glutamate-rich 1
    5. XM_006523759.4XP_006523822.1  afadin isoform X10

      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05672
      Location:16021686
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:14851705
      DUF5401; Family of unknown function (DUF5401)
    6. XM_006523764.4XP_006523827.1  afadin isoform X19

      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612940
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10161098
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05672
      Location:16021686
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:14851705
      DUF5401; Family of unknown function (DUF5401)
    7. XM_006523757.4XP_006523820.1  afadin isoform X6

      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10091091
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15921691
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14581710
      DUF5401; Family of unknown function (DUF5401)
    8. XM_006523766.4XP_006523829.1  afadin isoform X18

      Related
      ENSMUSP00000114485.2, ENSMUST00000137708.8
      Conserved Domains (7) summary
      cd00060
      Location:418500
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:612933
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10091091
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15921691
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14581710
      DUF5401; Family of unknown function (DUF5401)
    9. XM_006523760.4XP_006523823.1  afadin isoform X11

      Conserved Domains (7) summary
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:597925
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10011083
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15841683
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14501702
      DUF5401; Family of unknown function (DUF5401)
    10. XM_030249528.2XP_030105388.1  afadin isoform X21

      Conserved Domains (7) summary
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:597925
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10011083
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05672
      Location:15871671
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:14701690
      DUF5401; Family of unknown function (DUF5401)
    11. XM_030249526.2XP_030105386.1  afadin isoform X14

      Conserved Domains (7) summary
      cd00060
      Location:385485
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:597918
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:248348
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:9941076
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15771676
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14431695
      DUF5401; Family of unknown function (DUF5401)
    12. XM_006523754.4XP_006523817.1  afadin isoform X3

      Conserved Domains (7) summary
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15981697
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14641716
      DUF5401; Family of unknown function (DUF5401)
    13. XM_017317275.3XP_017172764.1  afadin isoform X8

      Conserved Domains (7) summary
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20132
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15911690
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14571709
      DUF5401; Family of unknown function (DUF5401)
    14. XM_006523753.4XP_006523816.1  afadin isoform X2

      Conserved Domains (7) summary
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15981697
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14641716
      DUF5401; Family of unknown function (DUF5401)
    15. XM_006523765.4XP_006523828.1  afadin isoform X20

      UniProtKB/TrEMBL
      E9Q9C3
      Related
      ENSMUSP00000119153.2, ENSMUST00000137784.8
      Conserved Domains (7) summary
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611939
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10151097
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05672
      Location:16011685
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:14841704
      DUF5401; Family of unknown function (DUF5401)
    16. XM_006523758.4XP_006523821.1  afadin isoform X7

      Conserved Domains (7) summary
      cd00060
      Location:417499
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:611932
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10081090
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15911690
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14571709
      DUF5401; Family of unknown function (DUF5401)
    17. XM_036160347.1XP_036016240.1  afadin isoform X12

      Conserved Domains (6) summary
      cd00060
      Location:384484
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:596924
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:247347
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10001082
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15709
      Location:15071681
      DUF4670; Domain of unknown function (DUF4670)
    18. XM_006523756.4XP_006523819.1  afadin isoform X5

      Conserved Domains (7) summary
      cd00060
      Location:416498
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610938
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:246346
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10141096
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15971696
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14631715
      DUF5401; Family of unknown function (DUF5401)
    19. XM_017317276.3XP_017172765.1  afadin isoform X9

      Conserved Domains (7) summary
      cd00060
      Location:416498
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:610931
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:246346
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:10071089
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15901689
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14561708
      DUF5401; Family of unknown function (DUF5401)
    20. XM_036160348.1XP_036016241.1  afadin isoform X13

      Conserved Domains (6) summary
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595923
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:246346
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:9991081
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15709
      Location:15061680
      DUF4670; Domain of unknown function (DUF4670)
    21. XM_006523762.4XP_006523825.1  afadin isoform X15

      Conserved Domains (7) summary
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:246346
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam15346
      Location:15751674
      ARGLU; Arginine and glutamate-rich 1
      pfam17380
      Location:14411693
      DUF5401; Family of unknown function (DUF5401)
    22. XM_006523767.4XP_006523830.1  afadin isoform X22

      Conserved Domains (7) summary
      cd00060
      Location:383483
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd15471
      Location:595916
      Myo5p-like_CBD_afadin; cargo binding domain of myosin 5-like of afadin
      cd01781
      Location:246346
      RA2_Afadin; Ras-associating (RA) domain 2 found in Afadin
      cd01782
      Location:20131
      RA1_Afadin; Ras-associating (RA) domain 1 found in Afadin
      pfam00595
      Location:9921074
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam05672
      Location:15781662
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:14611681
      DUF5401; Family of unknown function (DUF5401)

    RNA

    1. XR_385293.4 RNA Sequence

    2. XR_001782046.3 RNA Sequence

    3. XR_001782047.3 RNA Sequence

    4. XR_003952091.2 RNA Sequence

    Support Center