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    Mllt10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 [ Mus musculus (house mouse) ]

    Gene ID: 17354, updated on 2-Aug-2021

    Summary

    Official Symbol
    Mllt10provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10provided by MGI
    Primary source
    MGI:MGI:1329038
    See related
    Ensembl:ENSMUSG00000026743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Af1; Af10; mKIAA4140; B130021D15Rik; D630001B22Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mllt10 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (18059971..18217201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (18055160..18212390)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (17976898..18134017)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930004D18 gene Neighboring gene predicted gene, 33085 Neighboring gene predicted gene, 17762 Neighboring gene SKI/DACH domain containing 1 Neighboring gene microRNA 7655 Neighboring gene predicted gene, 25147 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C1 Neighboring gene GAR1 ribonucleoprotein homolog pseudogene Neighboring gene nuclear encoded tRNA asparagine 9 (anticodon GTT)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4140

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    protein AF-10
    Names
    myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252560.1NP_001239489.1  protein AF-10 isoform 1

      See identical proteins and their annotated locations for NP_001239489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AL928557, AL928589
      Consensus CDS
      CCDS15708.1
      UniProtKB/Swiss-Prot
      O54826
      Related
      ENSMUSP00000110328.3, ENSMUST00000114680.9
      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    2. NM_001252561.1NP_001239490.1  protein AF-10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate exon and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL928557, AL928589
      Consensus CDS
      CCDS57155.1
      UniProtKB/TrEMBL
      A2AS70
      Related
      ENSMUSP00000110319.2, ENSMUST00000114671.8
      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    3. NM_010804.4NP_034934.2  protein AF-10 isoform 1

      See identical proteins and their annotated locations for NP_034934.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BC070475, BY608946, CN534499, CN537566
      Consensus CDS
      CCDS15708.1
      UniProtKB/Swiss-Prot
      O54826
      Related
      ENSMUSP00000028076.9, ENSMUST00000028076.15
      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins

    RNA

    1. NR_045538.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK045042, AK052207, AL928557, AL928589, BC070475
    2. NR_045539.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site and contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL928557, AL928589
    3. NR_149308.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK045042, AK158426, AL928557

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      18059971..18217201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248197.2XP_030104057.1  protein AF-10 isoform X13

      Conserved Domains (2) summary
      cd20901
      Location:598661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:187
      PHD_SF; PHD finger superfamily
    2. XM_030248200.2XP_030104060.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    3. XM_030248116.2XP_030103976.1  protein AF-10 isoform X1

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    4. XM_006497389.4XP_006497452.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    5. XM_006497390.4XP_006497453.1  protein AF-10 isoform X16

      Conserved Domains (1) summary
      cl22851
      Location:152
      PHD_SF; PHD finger superfamily
    6. XM_006497373.5XP_006497436.2  protein AF-10 isoform X1

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    7. XM_036159019.1XP_036014912.1  protein AF-10 isoform X2

      Conserved Domains (3) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:706769
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    8. XM_006497375.5XP_006497438.2  protein AF-10 isoform X3

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    9. XM_030248112.2XP_030103972.1  protein AF-10 isoform X6

      Conserved Domains (3) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81151
      PHD_SF; PHD finger superfamily
    10. XM_006497382.5XP_006497445.2  protein AF-10 isoform X5

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    11. XM_006497377.5XP_006497440.2  protein AF-10 isoform X4

      UniProtKB/Swiss-Prot
      O54826
      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    12. XM_017316073.3XP_017171562.1  protein AF-10 isoform X7

      Conserved Domains (3) summary
      sd00025
      Location:6685
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    13. XM_036159032.1XP_036014925.1  protein AF-10 isoform X9

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    14. XM_030248136.2XP_030103996.1  protein AF-10 isoform X8

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    15. XM_030248168.2XP_030104028.1  protein AF-10 isoform X9

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    16. XM_036159035.1XP_036014928.1  protein AF-10 isoform X11

      Conserved Domains (2) summary
      cd15708
      Location:3125
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:607670
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    17. XM_030248139.2XP_030103999.1  protein AF-10 isoform X8

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    18. XM_030248178.2XP_030104038.1  protein AF-10 isoform X9

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    19. XM_030248113.2XP_030103973.1  protein AF-10 isoform X1

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    20. XM_030248120.2XP_030103980.1  protein AF-10 isoform X3

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    21. XM_036159034.1XP_036014927.1  protein AF-10 isoform X10

      Conserved Domains (3) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:630693
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81148
      PHD_SF; PHD finger superfamily
    22. XM_036159027.1XP_036014920.1  protein AF-10 isoform X8

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    23. XM_030248154.2XP_030104014.1  protein AF-10 isoform X8

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    24. XM_030248187.2XP_030104047.1  protein AF-10 isoform X9

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    25. XM_036159033.1XP_036014926.1  protein AF-10 isoform X9

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    26. XM_030248193.2XP_030104053.1  protein AF-10 isoform X11

      Conserved Domains (2) summary
      cd15708
      Location:3125
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:607670
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    27. XM_030248114.2XP_030103974.1  protein AF-10 isoform X1

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78206
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    28. XM_030248127.2XP_030103987.1  protein AF-10 isoform X3

      Conserved Domains (2) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd15708
      Location:78203
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
    29. XM_036159031.1XP_036014924.1  protein AF-10 isoform X6

      Conserved Domains (3) summary
      cd15574
      Location:2471
      PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:81151
      PHD_SF; PHD finger superfamily
    30. XM_030248156.2XP_030104016.1  protein AF-10 isoform X8

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:662725
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    31. XM_036159037.1XP_036014930.1  protein AF-10 isoform X13

      Conserved Domains (2) summary
      cd20901
      Location:598661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:187
      PHD_SF; PHD finger superfamily
    32. XM_036159048.1XP_036014941.1  protein AF-10 isoform X17

      Conserved Domains (2) summary
      cd20901
      Location:552615
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:370
      PHD_SF; PHD finger superfamily
    33. XM_030248195.2XP_030104055.1  protein AF-10 isoform X13

      Conserved Domains (2) summary
      cd20901
      Location:598661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:187
      PHD_SF; PHD finger superfamily
    34. XM_036159041.1XP_036014934.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    35. XM_036159038.1XP_036014931.1  protein AF-10 isoform X14

      Conserved Domains (2) summary
      cd20901
      Location:584647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:373
      PHD_SF; PHD finger superfamily
    36. XM_036159040.1XP_036014933.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    37. XM_036159044.1XP_036014937.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    38. XM_017316080.3XP_017171569.1  protein AF-10 isoform X16

      Conserved Domains (1) summary
      cl22851
      Location:152
      PHD_SF; PHD finger superfamily
    39. XM_036159039.1XP_036014932.1  protein AF-10 isoform X14

      Conserved Domains (2) summary
      cd20901
      Location:584647
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:373
      PHD_SF; PHD finger superfamily
    40. XM_036159049.1XP_036014942.1  protein AF-10 isoform X17

      Conserved Domains (2) summary
      cd20901
      Location:552615
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:370
      PHD_SF; PHD finger superfamily
    41. XM_030248196.2XP_030104056.1  protein AF-10 isoform X13

      Conserved Domains (2) summary
      cd20901
      Location:598661
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:187
      PHD_SF; PHD finger superfamily
    42. XM_036159042.1XP_036014935.1  protein AF-10 isoform X15

      Conserved Domains (2) summary
      cd20901
      Location:566629
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
      cl22851
      Location:184
      PHD_SF; PHD finger superfamily
    43. XM_030248194.2XP_030104054.1  protein AF-10 isoform X12

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    44. XM_036159036.1XP_036014929.1  protein AF-10 isoform X12

      Conserved Domains (2) summary
      cd15708
      Location:3128
      ePHD_AF10; Extended PHD finger found in protein AF-10 and similar proteins
      cd20901
      Location:639702
      CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins
    45. XM_030248210.2XP_030104070.1  protein AF-10 isoform X18

      Conserved Domains (1) summary
      cl22851
      Location:373
      PHD_SF; PHD finger superfamily
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