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    Mknk1 MAP kinase-interacting serine/threonine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 17346, updated on 12-Sep-2021

    Summary

    Official Symbol
    Mknk1provided by MGI
    Official Full Name
    MAP kinase-interacting serine/threonine kinase 1provided by MGI
    Primary source
    MGI:MGI:894316
    See related
    Ensembl:ENSMUSG00000028708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mnk; Mnk1; 2410048M24Rik
    Summary
    This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mknk1 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115695140..115736453)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115837943..115879256)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (115511851..115551853)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1 Neighboring gene MOB kinase activator 3C Neighboring gene RIKEN cDNA 6430628N08 gene Neighboring gene kinocilin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAPK signal-integrating kinase 1
    NP_001272416.1
    NP_001272417.1
    NP_001342103.1
    NP_001356167.1
    NP_067436.1
    XP_006502885.1
    XP_006502888.1
    XP_030109148.1
    XP_036019677.1
    XP_036019678.1
    XP_036019679.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285487.1NP_001272416.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform a

      See identical proteins and their annotated locations for NP_001272416.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK141298, AL627085, BB841753, BQ551007, BY209061, CN538557, CO425179
      UniProtKB/TrEMBL
      Q3U1I8
      Related
      ENSMUST00000144235.8
      Conserved Domains (1) summary
      cd14174
      Location:40328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    2. NM_001285488.1NP_001272417.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

      See identical proteins and their annotated locations for NP_001272417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK141298, AL627085, BQ551007, BY209061, CN538557, CO425179
      Consensus CDS
      CCDS18498.1
      UniProtKB/Swiss-Prot
      O08605
      UniProtKB/TrEMBL
      A2A8W8
      Related
      ENSMUSP00000102123.4, ENSMUST00000106513.10
      Conserved Domains (2) summary
      smart00220
      Location:41321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:34322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    3. NM_001355174.1NP_001342103.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AK141298, BP762163, BQ551007, BY209061, CN538557, CO425179
      Conserved Domains (1) summary
      cd14174
      Location:34322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    4. NM_001369238.1NP_001356167.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL627085
      Conserved Domains (1) summary
      cl21453
      Location:34290
      PKc_like; Protein Kinases, catalytic domain
    5. NM_021461.5NP_067436.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform b

      See identical proteins and their annotated locations for NP_067436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK141298, BQ551007, BY209061, CN538557, CO425179
      Consensus CDS
      CCDS18498.1
      UniProtKB/Swiss-Prot
      O08605
      UniProtKB/TrEMBL
      A2A8W8
      Related
      ENSMUSP00000019677.6, ENSMUST00000019677.12
      Conserved Domains (2) summary
      smart00220
      Location:41321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:34322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115695140..115736453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163785.1XP_036019678.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

      Conserved Domains (1) summary
      cd14174
      Location:34322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    2. XM_006502822.4XP_006502885.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006502885.1

      UniProtKB/TrEMBL
      Q3U1I8
      Conserved Domains (1) summary
      cd14174
      Location:40328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    3. XM_006502825.4XP_006502888.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      Conserved Domains (1) summary
      cd14174
      Location:40328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    4. XM_036163784.1XP_036019677.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      Conserved Domains (1) summary
      cd14174
      Location:38326
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
    5. XM_036163786.1XP_036019679.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:31235
      PKc_like; Protein Kinases, catalytic domain
    6. XM_030253288.2XP_030109148.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      Conserved Domains (1) summary
      cd14174
      Location:38326
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
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