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    Mki67 antigen identified by monoclonal antibody Ki 67 [ Mus musculus (house mouse) ]

    Gene ID: 17345, updated on 18-Jun-2024

    Summary

    Official Symbol
    Mki67provided by MGI
    Official Full Name
    antigen identified by monoclonal antibody Ki 67provided by MGI
    Primary source
    MGI:MGI:106035
    See related
    Ensembl:ENSMUSG00000031004 AllianceGenome:MGI:106035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki67; Ki-67; D630048A14Rik
    Summary
    Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mki67 in Genome Data Viewer
    Location:
    7 F3; 7 81.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135291513..135318286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135689784..135716450, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type E Neighboring gene microRNA 1962 Neighboring gene STARR-seq mESC enhancer starr_20364 Neighboring gene STARR-seq mESC enhancer starr_20365 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142829243-142829444 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142844161-142844270 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142849909-142850110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142860527-142860728 Neighboring gene STARR-positive B cell enhancer ABC_E1096 Neighboring gene STARR-positive B cell enhancer ABC_E1745 Neighboring gene STARR-positive B cell enhancer ABC_E8218 Neighboring gene predicted gene, 36431 Neighboring gene RIKEN cDNA 6330420H09 gene Neighboring gene predicted gene 45241

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    proliferation marker protein Ki-67
    Names
    antigen KI-67 homolog
    antigen Ki67 homolog
    antigen identified by monoclonal antibody Ki-67 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081117.2NP_001074586.2  proliferation marker protein Ki-67

      Status: VALIDATED

      Source sequence(s)
      AC123047, AK052772, AK143677, BC053453
      Consensus CDS
      CCDS52421.1
      UniProtKB/Swiss-Prot
      E9PVX6, Q61769, Q7TSF6
      Related
      ENSMUSP00000033310.8, ENSMUST00000033310.9
      Conserved Domains (4) summary
      COG1716
      Location:1192
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:7101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:11091216
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:463529
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      135291513..135318286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507413.5XP_006507476.1  proliferation marker protein Ki-67 isoform X2

      Conserved Domains (3) summary
      cd00060
      Location:7101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:18541964
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:143184
      PP1_bind; Protein phosphatase 1 binding
    2. XM_036152742.1XP_036008635.1  proliferation marker protein Ki-67 isoform X1

      Conserved Domains (2) summary
      pfam08065
      Location:20302140
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:318360
      PP1_bind; Protein phosphatase 1 binding