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    Pias2 protein inhibitor of activated STAT 2 [ Mus musculus (house mouse) ]

    Gene ID: 17344, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pias2provided by MGI
    Official Full Name
    protein inhibitor of activated STAT 2provided by MGI
    Primary source
    MGI:MGI:1096566
    See related
    Ensembl:ENSMUSG00000025423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Di; PI; DIP; Dib; Miz; Miz1; PIAS; SIZ2; ARIP3; PIASxb; AI462206; AU018068; PIASxbeta; PIASxalpha; PIASxalpha6
    Expression
    Broad expression in testis adult (RPKM 36.6), CNS E14 (RPKM 8.7) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pias2 in Genome Data Viewer
    Location:
    18; 18 E3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77152883..77243406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77065176..77155710)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (77303947..77394447)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene katanin p60 subunit A-like 2 Neighboring gene RIKEN cDNA 4930520E11 gene Neighboring gene predicted gene 7276 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 Neighboring gene lipoxygenase homology domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 SUMO-protein ligase PIAS2
    Names
    DAB2-interacting protein
    Msx-interacting-zinc finger
    RING-type E3 ubiquitin transferase PIAS2
    androgen receptor-interacting protein 3
    msx-interacting zinc finger protein
    protein inhibitor of activated STAT x
    NP_001157639.1
    NP_001157640.1
    NP_001157641.1
    NP_001157642.1
    NP_032628.3
    XP_006526486.1
    XP_006526488.1
    XP_036016910.1
    XP_036016911.1
    XP_036016912.1
    XP_036016913.1
    XP_036016914.1
    XP_036016916.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164167.1NP_001157639.1  E3 SUMO-protein ligase PIAS2 isoform 2

      See identical proteins and their annotated locations for NP_001157639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. This results in a frameshift and distinct C-terminus in isoform 2, compared to isoform 1.
      Source sequence(s)
      AK029716, AK032463, AK086653
      UniProtKB/Swiss-Prot
      Q8C5D8
      UniProtKB/TrEMBL
      Q3V3U5
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145282
      PINIT; PINIT domain
    2. NM_001164168.1NP_001157640.1  E3 SUMO-protein ligase PIAS2 isoform 3

      See identical proteins and their annotated locations for NP_001157640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK032463, AK086653, BU704371
      Consensus CDS
      CCDS50324.1
      UniProtKB/Swiss-Prot
      Q8C5D8
      UniProtKB/TrEMBL
      G3UWE3, Q3V3U5
      Related
      ENSMUSP00000131485.2, ENSMUST00000168882.9
      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:335383
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:138275
      PINIT; PINIT domain
    3. NM_001164169.1NP_001157641.1  E3 SUMO-protein ligase PIAS2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, resulting in a translational frameshift, compared to variant 1. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC157991, AK014871, AK029716
      UniProtKB/Swiss-Prot
      Q8C5D8
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145282
      PINIT; PINIT domain
    4. NM_001164170.1NP_001157642.1  E3 SUMO-protein ligase PIAS2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct N- and C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC157991, AK014871, AK086653, BU704371
      Consensus CDS
      CCDS50323.1
      UniProtKB/Swiss-Prot
      Q8C5D8
      UniProtKB/TrEMBL
      F8WHS8
      Related
      ENSMUSP00000110424.3, ENSMUST00000114776.4
      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:335383
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:138275
      PINIT; PINIT domain
    5. NM_008602.4NP_032628.3  E3 SUMO-protein ligase PIAS2 isoform 1

      See identical proteins and their annotated locations for NP_032628.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC157991, AK029716, AK032463
      Consensus CDS
      CCDS37866.1
      UniProtKB/Swiss-Prot
      Q8C5D8
      UniProtKB/TrEMBL
      Q3V3U5
      Related
      ENSMUSP00000110425.3, ENSMUST00000114777.10
      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:342390
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:145282
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77152883..77243406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526423.4XP_006526486.1  E3 SUMO-protein ligase PIAS2 isoform X1

      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147291
      PINIT; PINIT domain
    2. XM_036161018.1XP_036016911.1  E3 SUMO-protein ligase PIAS2 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain
    3. XM_036161019.1XP_036016912.1  E3 SUMO-protein ligase PIAS2 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain
    4. XM_036161020.1XP_036016913.1  E3 SUMO-protein ligase PIAS2 isoform X4

      Conserved Domains (3) summary
      smart00513
      Location:1145
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:343390
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:147296
      PINIT; PINIT domain
    5. XM_006526425.4XP_006526488.1  E3 SUMO-protein ligase PIAS2 isoform X2

      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:140284
      PINIT; PINIT domain
    6. XM_036161017.1XP_036016910.1  E3 SUMO-protein ligase PIAS2 isoform X3

      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:140289
      PINIT; PINIT domain
    7. XM_036161021.1XP_036016914.1  E3 SUMO-protein ligase PIAS2 isoform X5

      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:140289
      PINIT; PINIT domain
    8. XM_036161023.1XP_036016916.1  E3 SUMO-protein ligase PIAS2 isoform X5

      Conserved Domains (3) summary
      smart00513
      Location:438
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd16790
      Location:336383
      SP-RING_PIAS; SP-RING finger found in protein inhibitor of activated signal transducer and activator of transcription (PIAS) proteins
      pfam14324
      Location:140289
      PINIT; PINIT domain

    RNA

    1. XR_001782348.3 RNA Sequence

    2. XR_001782349.3 RNA Sequence

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