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    Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]

    Gene ID: 17283, updated on 5-Nov-2024

    Summary

    Official Symbol
    Men1provided by MGI
    Official Full Name
    multiple endocrine neoplasia 1provided by MGI
    Primary source
    MGI:MGI:1316736
    See related
    Ensembl:ENSMUSG00000024947 AllianceGenome:MGI:1316736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of gene expression; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 36.9), ovary adult (RPKM 36.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Men1 in Genome Data Viewer
    Location:
    19 4.45 cM; 19 A
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6385009..6390924)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6334979..6340894)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene EH-domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_45427 Neighboring gene predicted gene, 52380 Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene CDC42 binding protein kinase gamma Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene predicted gene, 57665

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T-helper 2 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of fibroblast apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within leukocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maternal process involved in female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of organ growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of organ growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoblast fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to transforming growth factor beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of type B pancreatic cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168488.1NP_001161960.1  menin isoform a

      See identical proteins and their annotated locations for NP_001161960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC127556, AF016398, BY619391, CF170561
      Consensus CDS
      CCDS50366.1
      UniProtKB/TrEMBL
      A0A0R4J1I3, F8WHD9
      Related
      ENSMUSP00000109130.4, ENSMUST00000113502.10
      Conserved Domains (2) summary
      cd14456
      Location:9464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:8615
      Menin; Menin
    2. NM_001168489.1NP_001161961.1  menin isoform b

      See identical proteins and their annotated locations for NP_001161961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC127556, AF016398, BY619391
      Consensus CDS
      CCDS29502.1
      UniProtKB/Swiss-Prot
      O88559, Q3U491, Q8CI72, Q91UZ7
      UniProtKB/TrEMBL
      F8WHD9
      Related
      ENSMUSP00000078306.6, ENSMUST00000079327.12
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2609
      Menin; Menin
    3. NM_001168490.1NP_001161962.1  menin isoform c

      See identical proteins and their annotated locations for NP_001161962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AF016398, BY319905, BY619391, CX568988
      Consensus CDS
      CCDS50367.1
      UniProtKB/TrEMBL
      F8WHD9
      Related
      ENSMUSP00000077272.6, ENSMUST00000078137.12
      Conserved Domains (2) summary
      cd14456
      Location:3390
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2554
      Menin; Menin
    4. NM_008583.2NP_032609.1  menin isoform b

      See identical proteins and their annotated locations for NP_032609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AF016398, BY319905, BY619391, CX568988
      Consensus CDS
      CCDS29502.1
      UniProtKB/Swiss-Prot
      O88559, Q3U491, Q8CI72, Q91UZ7
      UniProtKB/TrEMBL
      F8WHD9
      Related
      ENSMUSP00000058149.9, ENSMUST00000056391.15
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2609
      Menin; Menin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6385009..6390924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)