Format

Send to:

Choose Destination
    • Showing Current items.

    Men1 multiple endocrine neoplasia 1 [ Mus musculus (house mouse) ]

    Gene ID: 17283, updated on 28-Oct-2018

    Summary

    Official Symbol
    Men1provided by MGI
    Official Full Name
    multiple endocrine neoplasia 1provided by MGI
    Primary source
    MGI:MGI:1316736
    See related
    Ensembl:ENSMUSG00000024947 Vega:OTTMUSG00000018611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW045611
    Expression
    Ubiquitous expression in thymus adult (RPKM 36.9), ovary adult (RPKM 36.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Men1 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (6334979..6340894)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (6334979..6340894)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene EH-domain containing 1 Neighboring gene CDC42 binding protein kinase gamma (DMPK-like) Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989 Neighboring gene predicted gene 14966 Neighboring gene splicing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    Y-form DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal process involved in female pregnancy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of organ growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast development ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to transforming growth factor beta ISO
    Inferred from Sequence Orthology
    more info
     
    roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type B pancreatic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168488.1NP_001161960.1  menin isoform a

      See identical proteins and their annotated locations for NP_001161960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC127556, AF016398, BY619391, CF170561
      Consensus CDS
      CCDS50366.1
      UniProtKB/Swiss-Prot
      O88559
      UniProtKB/TrEMBL
      A0A0R4J1I3
      Related
      ENSMUSP00000109130.3, ENSMUST00000113502.9
      Conserved Domains (2) summary
      cd14456
      Location:9464
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:8615
      Menin; Menin
    2. NM_001168489.1NP_001161961.1  menin isoform b

      See identical proteins and their annotated locations for NP_001161961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC127556, AF016398, BY619391
      Consensus CDS
      CCDS29502.1
      UniProtKB/Swiss-Prot
      O88559
      Related
      ENSMUSP00000078306.5, OTTMUSP00000020153, ENSMUST00000079327.11, OTTMUST00000044787
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2609
      Menin; Menin
    3. NM_001168490.1NP_001161962.1  menin isoform c

      See identical proteins and their annotated locations for NP_001161962.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AF016398, BY319905, BY619391, CX568988
      Consensus CDS
      CCDS50367.1
      UniProtKB/Swiss-Prot
      O88559
      Related
      ENSMUSP00000077272.5, OTTMUSP00000020155, ENSMUST00000078137.11, OTTMUST00000044789
      Conserved Domains (2) summary
      cd14456
      Location:3390
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2554
      Menin; Menin
    4. NM_008583.2NP_032609.1  menin isoform b

      See identical proteins and their annotated locations for NP_032609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AF016398, BY319905, BY619391, CX568988
      Consensus CDS
      CCDS29502.1
      UniProtKB/Swiss-Prot
      O88559
      Related
      ENSMUSP00000058149.8, OTTMUSP00000020154, ENSMUST00000056391.14, OTTMUST00000044788
      Conserved Domains (2) summary
      cd14456
      Location:3458
      Menin; Scaffolding protein menin encoded by the MEN1 gene
      pfam05053
      Location:2609
      Menin; Menin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      6334979..6340894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_012132910.1 Reference GRCm38.p4 PATCHES

      Range
      151896..157811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center