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    Melk maternal embryonic leucine zipper kinase [ Mus musculus (house mouse) ]

    Gene ID: 17279, updated on 27-Nov-2024

    Summary

    Official Symbol
    Melkprovided by MGI
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by MGI
    Primary source
    MGI:MGI:106924
    See related
    Ensembl:ENSMUSG00000035683 AllianceGenome:MGI:106924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPK38; mKIAA0175
    Summary
    Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 14.4), placenta adult (RPKM 9.4) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Melk in Genome Data Viewer
    Location:
    4 B1; 4 23.46 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44300876..44364301)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44300909..44364675)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 38 Neighboring gene microRNA 5106 Neighboring gene STARR-seq mESC enhancer starr_10071 Neighboring gene STARR-seq mESC enhancer starr_10072 Neighboring gene predicted gene, 54218 Neighboring gene STARR-positive B cell enhancer ABC_E6169 Neighboring gene STARR-seq mESC enhancer starr_10073 Neighboring gene predicted gene, 24376 Neighboring gene STARR-seq mESC enhancer starr_10075 Neighboring gene STARR-seq mESC enhancer starr_10079 Neighboring gene paired box 5 Neighboring gene microRNA 5120

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural precursor cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    protein kinase PK38
    tyrosine-protein kinase MELK
    NP_001405928.1
    NP_001405929.1
    NP_034920.2
    XP_036019676.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418999.1NP_001405928.1  maternal embryonic leucine zipper kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL805952, AL807399
    2. NM_001419000.1NP_001405929.1  maternal embryonic leucine zipper kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL805952, AL807399
    3. NM_010790.3NP_034920.2  maternal embryonic leucine zipper kinase isoform 1

      See identical proteins and their annotated locations for NP_034920.2

      Status: VALIDATED

      Source sequence(s)
      AL805952, AL807399
      Consensus CDS
      CCDS18124.1
      UniProtKB/Swiss-Prot
      Q3TPU1, Q61804, Q61846, Q6ZQH6
      UniProtKB/TrEMBL
      Q3TJF3, Q3TU15
      Related
      ENSMUSP00000043806.6, ENSMUST00000045607.12
      Conserved Domains (4) summary
      cd12198
      Location:547641
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44300876..44364301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163783.1XP_036019676.1  maternal embryonic leucine zipper kinase isoform X2

      UniProtKB/TrEMBL
      Q3TU15
      Conserved Domains (2) summary
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase