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    Melk maternal embryonic leucine zipper kinase [ Mus musculus (house mouse) ]

    Gene ID: 17279, updated on 5-Sep-2021

    Summary

    Official Symbol
    Melkprovided by MGI
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by MGI
    Primary source
    MGI:MGI:106924
    See related
    Ensembl:ENSMUSG00000035683
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPK3; MPK38; AI327312; mKIAA0175
    Expression
    Biased expression in CNS E11.5 (RPKM 14.4), placenta adult (RPKM 9.4) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Melk in Genome Data Viewer
    Location:
    4 B1; 4 23.46 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44300876..44364675)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44300909..44364675)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (44313789..44377547)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 38 Neighboring gene microRNA 5106 Neighboring gene predicted gene, 54218 Neighboring gene predicted gene, 24376 Neighboring gene paired box 5 Neighboring gene microRNA 5120

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    protein kinase PK38
    tyrosine-protein kinase MELK
    NP_034920.2
    XP_006537703.1
    XP_036019676.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010790.2NP_034920.2  maternal embryonic leucine zipper kinase

      See identical proteins and their annotated locations for NP_034920.2

      Status: PROVISIONAL

      Source sequence(s)
      AK011932
      Consensus CDS
      CCDS18124.1
      UniProtKB/Swiss-Prot
      Q61846
      Related
      ENSMUSP00000043806.6, ENSMUST00000045607.12
      Conserved Domains (4) summary
      cd12198
      Location:547641
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:11263
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44300876..44364675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163783.1XP_036019676.1  maternal embryonic leucine zipper kinase isoform X2

      Conserved Domains (2) summary
      cd14341
      Location:281332
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:7263
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
    2. XM_006537640.4XP_006537703.1  maternal embryonic leucine zipper kinase isoform X1

      Conserved Domains (3) summary
      cd12198
      Location:491585
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      cd14341
      Location:225276
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cl21453
      Location:7222
      PKc_like; Protein Kinases, catalytic domain
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