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    Mea1 male enhanced antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 17256, updated on 16-Oct-2021

    Summary

    Official Symbol
    Mea1provided by MGI
    Official Full Name
    male enhanced antigen 1provided by MGI
    Primary source
    MGI:MGI:96957
    See related
    Ensembl:ENSMUSG00000002768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mea-1
    Expression
    Biased expression in testis adult (RPKM 378.2), CNS E18 (RPKM 37.2) and 13 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mea1 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46989727..46994052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46678801..46683126)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (46818086..46820054)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene ribosomal RNA processing 36 Neighboring gene kelch domain containing 3 Neighboring gene protein phosphatase 2, regulatory subunit B', delta Neighboring gene peroxisomal biogenesis factor 6 Neighboring gene glycine N-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277309.1NP_001264238.1  male-enhanced antigen 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK010904, BY510335, BY707372, CT030702
      UniProtKB/Swiss-Prot
      Q64327
      Conserved Domains (1) summary
      pfam06910
      Location:42215
      MEA1; Male enhanced antigen 1 (MEA1)
    2. NM_001277310.1NP_001264239.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BG085669, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327
      Related
      ENSMUSP00000156392.2, ENSMUST00000232732.2
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
    3. NM_001277311.1NP_001264240.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327
      Related
      ENSMUSP00000156895.2, ENSMUST00000232762.2
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
    4. NM_001277312.1NP_001264241.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_001264241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CT030702
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327
      Related
      ENSMUSP00000156967.2, ENSMUST00000233612.2
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
    5. NM_010787.2NP_034917.1  male-enhanced antigen 1 isoform b

      See identical proteins and their annotated locations for NP_034917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AK010904, BY510335, CJ042312
      Consensus CDS
      CCDS28835.1
      UniProtKB/Swiss-Prot
      Q64327
      Related
      ENSMUSP00000002845.7, ENSMUST00000002845.8
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)

    RNA

    1. NR_102392.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK008194, BY510335, CJ042312, CT030702

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46989727..46994052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523748.4XP_006523811.1  male-enhanced antigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006523811.1

      UniProtKB/Swiss-Prot
      Q64327
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
    2. XM_006523750.5XP_006523813.1  male-enhanced antigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006523813.1

      UniProtKB/Swiss-Prot
      Q64327
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
    3. XM_006523749.5XP_006523812.1  male-enhanced antigen 1 isoform X1

      See identical proteins and their annotated locations for XP_006523812.1

      UniProtKB/Swiss-Prot
      Q64327
      Conserved Domains (1) summary
      pfam06910
      Location:54170
      MEA1; Male enhanced antigen 1 (MEA1)
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