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    Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 17254, updated on 9-Sep-2018

    Summary

    Official Symbol
    Slc3a2provided by MGI
    Official Full Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2provided by MGI
    Primary source
    MGI:MGI:96955
    See related
    Ensembl:ENSMUSG00000010095 Vega:OTTMUSG00000057838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4F2; Cd98; Ly10; Mdu1; 4F2HC; Ly-10; NACAE; Ly-m10; Mgp-2hc; AI314110
    Expression
    Ubiquitous expression in kidney adult (RPKM 55.8), genital fat pad adult (RPKM 41.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Slc3a2 in Genome Data Viewer
    Location:
    19 A; 19 5.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (8706882..8723369, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8781372..8797859, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene cholinergic receptor, muscarinic 1, CNS Neighboring gene small nucleolar RNA, C/D box 22 Neighboring gene small nucleolar RNA host gene 1 Neighboring gene WD repeat domain 74

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neutral amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron part IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    4F2 cell-surface antigen heavy chain
    Names
    CD98 antigen
    CD98 heavy chain
    antigen identified by monoclonal antibodies 4F2
    solute carrier family 3 member 2
    type II transmembrane protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161413.1NP_001154885.1  4F2 cell-surface antigen heavy chain isoform a

      See identical proteins and their annotated locations for NP_001154885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
      Source sequence(s)
      AC025794, AK161280
      Consensus CDS
      CCDS50381.1
      UniProtKB/Swiss-Prot
      P10852
      Related
      ENSMUSP00000130194.1, OTTMUSP00000074143, ENSMUST00000170157.7, OTTMUST00000142012
      Conserved Domains (3) summary
      COG0366
      Location:169513
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
      pfam16028
      Location:85156
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl07893
      Location:139468
      AmyAc_family; Alpha amylase catalytic domain family
    2. NM_008577.4NP_032603.3  4F2 cell-surface antigen heavy chain isoform b

      See identical proteins and their annotated locations for NP_032603.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' coding region and 5' UTR, compared to variant 1. This results in a shorter and distinct N-terminus in isoform b, compared to isoform a.
      Source sequence(s)
      AC025794, AK165417, BU054912
      Consensus CDS
      CCDS29540.1
      UniProtKB/Swiss-Prot
      P10852
      Related
      ENSMUSP00000010239.4, OTTMUSP00000074145, ENSMUST00000010239.5, OTTMUST00000142014
      Conserved Domains (3) summary
      COG0366
      Location:130474
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
      pfam16028
      Location:46117
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl07893
      Location:100429
      AmyAc_family; Alpha amylase catalytic domain family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      8706882..8723369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318078.1XP_017173567.1  4F2 cell-surface antigen heavy chain isoform X1

      UniProtKB/Swiss-Prot
      P10852
      Conserved Domains (3) summary
      COG0366
      Location:130474
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
      pfam16028
      Location:46117
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl07893
      Location:100429
      AmyAc_family; Alpha amylase catalytic domain family
    2. XM_006526733.2XP_006526796.1  4F2 cell-surface antigen heavy chain isoform X2

      UniProtKB/TrEMBL
      A0A0U1RPK4
      Related
      ENSMUSP00000146016.1, OTTMUSP00000074144, ENSMUST00000206598.1, OTTMUST00000142013
      Conserved Domains (2) summary
      COG0366
      Location:1251
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
      cl07893
      Location:1206
      AmyAc_family; Alpha amylase catalytic domain family
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