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    Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 17254, updated on 14-Sep-2021

    Summary

    Official Symbol
    Slc3a2provided by MGI
    Official Full Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2provided by MGI
    Primary source
    MGI:MGI:96955
    See related
    Ensembl:ENSMUSG00000010095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4F2; Cd98; Ly-1; Ly10; Mdu1; 4F2HC; Ly-10; Ly-m1; NACAE; Ly-m10; Mgp-2h; Mgp-2hc; AI314110
    Expression
    Ubiquitous expression in kidney adult (RPKM 55.8), genital fat pad adult (RPKM 41.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc3a2 in Genome Data Viewer
    Location:
    19 A; 19 5.44 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8684246..8700733, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8706882..8723369, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8781372..8797859, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene cholinergic receptor, muscarinic 1, CNS Neighboring gene predicted gene, 25855 Neighboring gene predicted gene, 25894 Neighboring gene small nucleolar RNA host gene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aromatic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables neutral amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leucine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phenylalanine transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of amino acid transport complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical pole of neuron IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    4F2 cell-surface antigen heavy chain
    Names
    CD98 antigen
    CD98 heavy chain
    antigen identified by monoclonal antibodies 4F2
    solute carrier family 3 member 2
    type II transmembrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161413.1NP_001154885.1  4F2 cell-surface antigen heavy chain isoform a

      See identical proteins and their annotated locations for NP_001154885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
      Source sequence(s)
      AC025794, AK161280
      Consensus CDS
      CCDS50381.1
      UniProtKB/Swiss-Prot
      P10852
      Related
      ENSMUSP00000130194.2, ENSMUST00000170157.8
      Conserved Domains (3) summary
      COG0366
      Location:169513
      AmyA; Glycosidase [Carbohydrate transport and metabolism]
      pfam16028
      Location:85156
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl07893
      Location:139468
      AmyAc_family; Alpha amylase catalytic domain family
    2. NM_008577.4NP_032603.3  4F2 cell-surface antigen heavy chain isoform b

      See identical proteins and their annotated locations for NP_032603.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' coding region and 5' UTR, compared to variant 1. This results in a shorter and distinct N-terminus in isoform b, compared to isoform a.
      Source sequence(s)
      AC025794, AK165417, BU054912
      Consensus CDS
      CCDS29540.1
      UniProtKB/Swiss-Prot
      P10852
      Related
      ENSMUSP00000010239.5, ENSMUST00000010239.6
      Conserved Domains (2) summary
      pfam16028
      Location:45118
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl38930
      Location:100429
      AmyAc_family; Alpha amylase catalytic domain family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8684246..8700733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318078.3XP_017173567.1  4F2 cell-surface antigen heavy chain isoform X1

      UniProtKB/Swiss-Prot
      P10852
      Conserved Domains (2) summary
      pfam16028
      Location:45118
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl38930
      Location:100429
      AmyAc_family; Alpha amylase catalytic domain family
    2. XM_036161455.1XP_036017348.1  4F2 cell-surface antigen heavy chain isoform X1

      Conserved Domains (2) summary
      pfam16028
      Location:45118
      SLC3A2_N; Solute carrier family 3 member 2 N-terminus
      cl38930
      Location:100429
      AmyAc_family; Alpha amylase catalytic domain family
    3. XM_006526733.4XP_006526796.1  4F2 cell-surface antigen heavy chain isoform X2

      UniProtKB/TrEMBL
      A0A0U1RPK4
      Related
      ENSMUSP00000146016.2, ENSMUST00000206598.2
      Conserved Domains (2) summary
      TIGR02403
      Location:179297
      trehalose_treC; alpha,alpha-phosphotrehalase
      cl38930
      Location:1206
      AmyAc_family; Alpha amylase catalytic domain family
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