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    Mdm2 transformed mouse 3T3 cell double minute 2 [ Mus musculus (house mouse) ]

    Gene ID: 17246, updated on 5-Mar-2019

    Summary

    Official Symbol
    Mdm2provided by MGI
    Official Full Name
    transformed mouse 3T3 cell double minute 2provided by MGI
    Primary source
    MGI:MGI:96952
    See related
    Ensembl:ENSMUSG00000020184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdm-2; AA415488; 1700007J15Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 10.8), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mdm2 in Genome Data Viewer
    Location:
    10 D2; 10 66.32 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (117688875..117710758, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (117125961..117147772, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32365 Neighboring gene carboxypeptidase M Neighboring gene solute carrier family 35, member E3 Neighboring gene nucleoporin 107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    NEDD8 ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    atrioventricular valve morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to actinomycin D ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cushion morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocardial cushion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart valve development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine modification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to water-immersion restraint stress ISO
    Inferred from Sequence Orthology
    more info
     
    traversing start control point of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Mdm2
    Names
    RING-type E3 ubiquitin transferase Mdm2
    double minute 2 protein
    oncoprotein Mdm2
    p53-binding protein Mdm2
    NP_001275515.1
    NP_034916.1
    XP_017169311.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288586.2NP_001275515.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      See identical proteins and their annotated locations for NP_001275515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC050902, BP767471, BY323121, CN703560
      Consensus CDS
      CCDS70110.1
      UniProtKB/Swiss-Prot
      P23804
      Related
      ENSMUSP00000100898.1, ENSMUST00000105263.8
      Conserved Domains (3) summary
      pfam00641
      Location:248277
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:143
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:385432
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    2. NM_010786.4NP_034916.1  E3 ubiquitin-protein ligase Mdm2 isoform 1

      See identical proteins and their annotated locations for NP_034916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK004719, BP767471, BY323121
      Consensus CDS
      CCDS24194.1
      UniProtKB/Swiss-Prot
      P23804
      Related
      ENSMUSP00000020408.8, ENSMUST00000020408.15
      Conserved Domains (3) summary
      pfam00641
      Location:297326
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:4692
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:434481
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      117688875..117710758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313822.1XP_017169311.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

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