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    Anapc1 anaphase promoting complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 17222, updated on 26-Sep-2022

    Summary

    Official Symbol
    Anapc1provided by MGI
    Official Full Name
    anaphase promoting complex subunit 1provided by MGI
    Primary source
    MGI:MGI:103097
    See related
    Ensembl:ENSMUSG00000014355 AllianceGenome:MGI:103097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apc1; Mcpr; tsg24; 2610021O03Rik
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in nucleus. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Anapc1 in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128452003..128529558, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128610083..128687406, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene predicted gene, 39929 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    anaphase-promoting complex subunit 1
    Names
    cyclosome subunit 1
    meiotic check point regulator
    mitotic checkpoint regulator
    testis-specific gene 24 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008569.2NP_032595.2  anaphase-promoting complex subunit 1

      See identical proteins and their annotated locations for NP_032595.2

      Status: VALIDATED

      Source sequence(s)
      AK034858, AK077847, BB676785, BC139002, BE987509
      Consensus CDS
      CCDS16715.1
      UniProtKB/Swiss-Prot
      P53995, Q8C772
      Related
      ENSMUSP00000014499.4, ENSMUST00000014499.10
      Conserved Domains (2) summary
      pfam01851
      Location:14671501
      PC_rep; Proteasome/cyclosome repeat
      pfam12859
      Location:150218
      ANAPC1; Anaphase-promoting complex subunit 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128452003..128529558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248086.2XP_030103946.1  anaphase-promoting complex subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam01851
      Location:13491383
      PC_rep; Proteasome/cyclosome repeat
      pfam18122
      Location:16181777
      APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain
    2. XM_011239332.4XP_011237634.1  anaphase-promoting complex subunit 1 isoform X2

      Related
      ENSMUSP00000105962.2, ENSMUST00000110333.2
      Conserved Domains (1) summary
      pfam12859
      Location:150218
      ANAPC1; Anaphase-promoting complex subunit 1

    RNA

    1. XR_004938638.1 RNA Sequence