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    Mcm6 minichromosome maintenance complex component 6 [ Mus musculus (house mouse) ]

    Gene ID: 17219, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mcm6provided by MGI
    Official Full Name
    minichromosome maintenance complex component 6provided by MGI
    Primary source
    MGI:MGI:1298227
    See related
    Ensembl:ENSMUSG00000026355 Vega:OTTMUSG00000049360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcmd6; ASP-l1; D1Wsu22e
    Expression
    Biased expression in liver E14 (RPKM 53.6), liver E14.5 (RPKM 45.3) and 14 other tissues See more
    Orthologs

    Genomic context

    See Mcm6 in Genome Data Viewer
    Location:
    1 E3; 1 55.8 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (128331575..128359705, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (130228168..130256233, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41949 Neighboring gene UBX domain protein 4 Neighboring gene lactase Neighboring gene aspartyl-tRNA synthetase Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
     
    DNA unwinding involved in DNA replication IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MCM complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA replication licensing factor MCM6
    Names
    mini chromosome maintenance deficient 6
    minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
    NP_001300624.1
    NP_032593.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313695.1NP_001300624.1  DNA replication licensing factor MCM6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK078126, AK145520, BE447550, BY073760, CX202118
      Consensus CDS
      CCDS83586.1
      UniProtKB/TrEMBL
      Q3ULG5, Q8C5L1
      Related
      ENSMUSP00000140308.1, OTTMUSP00000068110, ENSMUST00000190495.1, OTTMUST00000125830
      Conserved Domains (3) summary
      smart00350
      Location:119657
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:29139
      MCM_N; MCM N-terminal domain
      cl21455
      Location:447534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_008567.2NP_032593.1  DNA replication licensing factor MCM6 isoform 1

      See identical proteins and their annotated locations for NP_032593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK146770, BE447550, BY073760
      Consensus CDS
      CCDS15252.1
      UniProtKB/Swiss-Prot
      P97311
      UniProtKB/TrEMBL
      Q542I2
      Related
      ENSMUSP00000027601.4, OTTMUSP00000068109, ENSMUST00000027601.10, OTTMUST00000125829
      Conserved Domains (3) summary
      smart00350
      Location:119657
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:29139
      MCM_N; MCM N-terminal domain
      cl21455
      Location:447534
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      128331575..128359705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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