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    Mcm2 minichromosome maintenance complex component 2 [ Mus musculus (house mouse) ]

    Gene ID: 17216, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mcm2provided by MGI
    Official Full Name
    minichromosome maintenance complex component 2provided by MGI
    Primary source
    MGI:MGI:105380
    See related
    Ensembl:ENSMUSG00000002870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BM28; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030
    Expression
    Broad expression in liver E14.5 (RPKM 77.8), liver E14 (RPKM 74.1) and 21 other tissues See more
    Orthologs

    Genomic context

    See Mcm2 in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (88883474..88898780, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (88833468..88848774, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and BTB (POZ) domain containing 1 Neighboring gene predicted gene 15612 Neighboring gene podocalyxin-like 2 Neighboring gene transmembrane protein, adipocyte asscociated 1 Neighboring gene predicted gene, 36268

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication initiation TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-4 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cochlea development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    MCM complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA replication licensing factor MCM2
    Names
    mini chromosome maintenance deficient 2
    minichromosome maintenance deficient 2 mitotin
    minichromosome maintenance protein 2 homolog
    nuclear protein BM28
    NP_032590.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008564.2NP_032590.2  DNA replication licensing factor MCM2

      See identical proteins and their annotated locations for NP_032590.2

      Status: VALIDATED

      Source sequence(s)
      AK129039, BY324067, CK378639
      Consensus CDS
      CCDS39554.1
      UniProtKB/Swiss-Prot
      P97310
      Related
      ENSMUSP00000061923.6, ENSMUST00000058011.7
      Conserved Domains (4) summary
      smart00350
      Location:291803
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:72182
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:198310
      MCM_N; MCM N-terminal domain
      cl21455
      Location:485632
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      88883474..88898780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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