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    H1f8 H1.8 linker histone [ Mus musculus (house mouse) ]

    Gene ID: 171506, updated on 19-Sep-2021

    Summary

    Official Symbol
    H1f8provided by MGI
    Official Full Name
    H1.8 linker histoneprovided by MGI
    Primary source
    MGI:MGI:2176207
    See related
    Ensembl:ENSMUSG00000042279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H1; H1f; H1-8; H1.8; H1fo; H1oo; H1foo; C86609
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward ovary adult (RPKM 8.4) See more
    Orthologs
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    Genomic context

    See H1f8 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115921892..115927203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115944931..115950242)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (115894957..115900251)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 4 Neighboring gene intraflagellar transport 122 Neighboring gene rhodopsin Neighboring gene rhodopsin enhancer region Neighboring gene plexin D1 Neighboring gene predicted gene, 53336

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleosome assembly ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in nucleosome positioning IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleosome positioning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H1.8
    Names
    H1 histone family, member O, oocyte-specific
    histone H1oo
    oocyte-specific histone H1
    oocyte-specific linker histone H1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346702.1NP_001333631.1  histone H1.8 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC142099, AK162154, DV655349
      Consensus CDS
      CCDS85133.1
      UniProtKB/Swiss-Prot
      Q8VIK3
      Related
      ENSMUSP00000123797.2, ENSMUST00000161969.4
    2. NM_138311.3NP_612184.1  histone H1.8 isoform 1

      See identical proteins and their annotated locations for NP_612184.1

      Status: REVIEWED

      Source sequence(s)
      AK135944, AV357657, CJ081178
      Consensus CDS
      CCDS20447.1
      UniProtKB/Swiss-Prot
      Q8VIK3
      Related
      ENSMUSP00000036951.8, ENSMUST00000037831.14
      Conserved Domains (1) summary
      cd00073
      Location:43134
      H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115921892..115927203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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