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    Mxd4 Max dimerization protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 17122, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mxd4provided by MGI
    Official Full Name
    Max dimerization protein 4provided by MGI
    Primary source
    MGI:MGI:104991
    See related
    Ensembl:ENSMUSG00000037235 AllianceGenome:MGI:104991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad4; bHLHc12; 2810410A03Rik
    Summary
    Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription, DNA-templated. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including craniocervical region bone; limb mesenchyme; neural tube; skin; and thymus. Orthologous to human MXD4 (MAX dimerization protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 161.0), thymus adult (RPKM 147.7) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Mxd4 in Genome Data Viewer
    Location:
    5 B2; 5 17.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34333924..34345054, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34176580..34187710, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DNA polymerase N Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene predicted gene, 25918 Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene zinc finger, FYVE domain containing 28 Neighboring gene cilia and flagella associated protein 99 Neighboring gene predicted gene 5553

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    max dimerization protein 4
    Names
    max dimerizer 4
    max-associated protein 4
    max-interacting transcriptional repressor MAD4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010753.3NP_034883.2  max dimerization protein 4

      See identical proteins and their annotated locations for NP_034883.2

      Status: VALIDATED

      Source sequence(s)
      AC157989
      Consensus CDS
      CCDS19212.1
      UniProtKB/TrEMBL
      Q91VN7
      Related
      ENSMUSP00000039071.7, ENSMUST00000042701.13
      Conserved Domains (1) summary
      cd18929
      Location:53140
      bHLHzip_Mad4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-associated protein 4 (Mad4) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      34333924..34345054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)