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    Mad1l1 MAD1 mitotic arrest deficient 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17120, updated on 2-Oct-2018

    Summary

    Official Symbol
    Mad1l1provided by MGI
    Official Full Name
    MAD1 mitotic arrest deficient 1-like 1provided by MGI
    Primary source
    MGI:MGI:1341857
    See related
    Ensembl:ENSMUSG00000029554 Vega:OTTMUSG00000030671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad1; AI173502; AW550425
    Expression
    Ubiquitous expression in thymus adult (RPKM 39.3), ovary adult (RPKM 12.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mad1l1 in Genome Data Viewer
    Location:
    5 G2; 5 78.82 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (140008689..140321586, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (140484643..140797506, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38727 Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1 Neighboring gene predicted gene, 30492 Neighboring gene predicted gene 16120 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene sorting nexin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle phase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymus development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitotic spindle assembly checkpoint protein MAD1
    Names
    MAD1-like protein 1
    mitotic arrest deficient 1-like 1
    mitotic arrest deficient 1-like protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359025.1NP_001345954.1  mitotic spindle assembly checkpoint protein MAD1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC121856, AC131670, AC137511, AC145748
      Conserved Domains (1) summary
      pfam05557
      Location:54715
      MAD; Mitotic checkpoint protein
    2. NM_001359027.1NP_001345956.1  mitotic spindle assembly checkpoint protein MAD1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC121856, AC145748
      Conserved Domains (1) summary
      cl25732
      Location:29292
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_010752.3NP_034882.2  mitotic spindle assembly checkpoint protein MAD1 isoform a

      See identical proteins and their annotated locations for NP_034882.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AF083812, BI735882
      Consensus CDS
      CCDS19817.1
      UniProtKB/Swiss-Prot
      Q9WTX8
      Related
      ENSMUSP00000031534.6, OTTMUSP00000039890, ENSMUST00000031534.8, OTTMUST00000075923
      Conserved Domains (1) summary
      pfam05557
      Location:54715
      MAD; Mitotic checkpoint protein

    RNA

    1. NR_152617.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC131670, AF083813

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      140008689..140321586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320696.1XP_017176185.1  mitotic spindle assembly checkpoint protein MAD1 isoform X4

    2. XM_006504652.3XP_006504715.1  mitotic spindle assembly checkpoint protein MAD1 isoform X2

      Conserved Domains (2) summary
      pfam05557
      Location:54668
      MAD; Mitotic checkpoint protein
      pfam16043
      Location:110258
      DUF4795; Domain of unknown function (DUF4795)
    3. XM_006504651.2XP_006504714.1  mitotic spindle assembly checkpoint protein MAD1 isoform X1

      UniProtKB/Swiss-Prot
      Q9WTX8
      Conserved Domains (1) summary
      pfam05557
      Location:54715
      MAD; Mitotic checkpoint protein
    4. XM_017320695.1XP_017176184.1  mitotic spindle assembly checkpoint protein MAD1 isoform X3

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