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    Mad1l1 MAD1 mitotic arrest deficient 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 17120, updated on 5-Sep-2021

    Summary

    Official Symbol
    Mad1l1provided by MGI
    Official Full Name
    MAD1 mitotic arrest deficient 1-like 1provided by MGI
    Primary source
    MGI:MGI:1341857
    See related
    Ensembl:ENSMUSG00000029554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad; Mad1; AI173502; AW550425
    Expression
    Ubiquitous expression in thymus adult (RPKM 39.3), ovary adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mad1l1 in Genome Data Viewer
    Location:
    5 G2; 5 78.82 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139994444..140307346, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140008689..140321608, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (140484643..140797506, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38727 Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1 Neighboring gene predicted gene, 30492 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene sorting nexin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinetochore binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitotic spindle assembly checkpoint protein MAD1
    Names
    MAD1-like protein 1
    mitotic arrest deficient 1-like 1
    mitotic arrest deficient 1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359025.1NP_001345954.1  mitotic spindle assembly checkpoint protein MAD1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC121856, AC131670, AC137511, AC145748
      Consensus CDS
      CCDS19817.1
      Conserved Domains (1) summary
      pfam05557
      Location:54715
      MAD; Mitotic checkpoint protein
    2. NM_001359027.1NP_001345956.1  mitotic spindle assembly checkpoint protein MAD1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC121856, AC145748
      Related
      ENSMUST00000199237.5
      Conserved Domains (1) summary
      cl25732
      Location:29292
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_010752.3NP_034882.2  mitotic spindle assembly checkpoint protein MAD1 isoform a

      See identical proteins and their annotated locations for NP_034882.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AF083812, BI735882
      Consensus CDS
      CCDS19817.1
      UniProtKB/Swiss-Prot
      Q9WTX8
      Related
      ENSMUSP00000031534.7, ENSMUST00000031534.9
      Conserved Domains (1) summary
      pfam05557
      Location:54715
      MAD; Mitotic checkpoint protein

    RNA

    1. NR_152617.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC131670, AF083813
      Related
      ENSMUST00000110829.7

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      139994444..140307346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504652.5XP_006504715.1  mitotic spindle assembly checkpoint protein MAD1 isoform X4

      Conserved Domains (1) summary
      pfam05557
      Location:54668
      MAD; Mitotic checkpoint protein
    2. XM_036164843.1XP_036020736.1  mitotic spindle assembly checkpoint protein MAD1 isoform X5

      Conserved Domains (1) summary
      pfam05557
      Location:19355
      MAD; Mitotic checkpoint protein
    3. XM_036164841.1XP_036020734.1  mitotic spindle assembly checkpoint protein MAD1 isoform X3

      Conserved Domains (1) summary
      pfam05557
      Location:54618
      MAD; Mitotic checkpoint protein
    4. XM_036164842.1XP_036020735.1  mitotic spindle assembly checkpoint protein MAD1 isoform X3

      Conserved Domains (1) summary
      pfam05557
      Location:54618
      MAD; Mitotic checkpoint protein
    5. XM_036164838.1XP_036020731.1  mitotic spindle assembly checkpoint protein MAD1 isoform X1

      Conserved Domains (1) summary
      pfam05557
      Location:54665
      MAD; Mitotic checkpoint protein
    6. XM_036164839.1XP_036020732.1  mitotic spindle assembly checkpoint protein MAD1 isoform X1

      Conserved Domains (1) summary
      pfam05557
      Location:54665
      MAD; Mitotic checkpoint protein
    7. XM_036164840.1XP_036020733.1  mitotic spindle assembly checkpoint protein MAD1 isoform X2

      Conserved Domains (1) summary
      pfam05557
      Location:54665
      MAD; Mitotic checkpoint protein
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