U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Mxd1 MAX dimerization protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17119, updated on 14-May-2024

    Summary

    Official Symbol
    Mxd1provided by MGI
    Official Full Name
    MAX dimerization protein 1provided by MGI
    Primary source
    MGI:MGI:96908
    See related
    Ensembl:ENSMUSG00000001156 AllianceGenome:MGI:96908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad; Mad1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including chromatin; mitochondrion; and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; integumental system; and sensory organ. Orthologous to human MXD1 (MAX dimerization protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in small intestine adult (RPKM 105.0), colon adult (RPKM 95.6) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6 D1; 6 37.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86624026..86646099, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86647044..86669234, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1600020E01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86543221-86543408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86557648-86557801 Neighboring gene aspartic peptidase, retroviral-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E860 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene germ cell-less, spermatogenesis associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Mad-Max complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    max dimerization protein 1
    Names
    max dimerizer 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410076.1NP_001397005.1  max dimerization protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158662
    2. NM_010751.4NP_034881.2  max dimerization protein 1 isoform 1

      See identical proteins and their annotated locations for NP_034881.2

      Status: VALIDATED

      Source sequence(s)
      AC158662
      Consensus CDS
      CCDS51835.1
      UniProtKB/Swiss-Prot
      P50538, Q60798, Q61825
      UniProtKB/TrEMBL
      Q4FK19, Q8K1Z8
      Related
      ENSMUSP00000001184.8, ENSMUST00000001184.10
      Conserved Domains (1) summary
      cd00083
      Location:53109
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

    RNA

    1. NR_176938.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158662

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86624026..86646099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)