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    Slc6a5 solute carrier family 6 member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171148, updated on 11-Apr-2024

    Summary

    Official Symbol
    Slc6a5provided by RGD
    Official Full Name
    solute carrier family 6 member 5provided by RGD
    Primary source
    RGD:621824
    See related
    Ensembl:ENSRNOG00000031662 AllianceGenome:RGD:621824
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GLYT2
    Summary
    Enables glycine transmembrane transporter activity. Involved in glycine transport and neurotransmitter uptake. Located in dense core granule and endosome. Is active in glycinergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 649.2) See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a5 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108767245..108833173)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99645389..99697016)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105270418..105336369)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene protein arginine methyltransferase 3 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53 Neighboring gene neural EGFL like 1 Neighboring gene uncharacterized LOC120097222 Neighboring gene 60S ribosomal protein L31-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycine:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter reuptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic transmission, glycinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic transmission, glycinergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glycinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glycinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium- and chloride-dependent glycine transporter 2
    Names
    glyT-2
    glycine transporter 2
    solute carrier family 6 (neurotransmitter transporter), member 5
    solute carrier family 6 (neurotransmitter transporter, glycine), member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203334.1NP_976079.1  sodium- and chloride-dependent glycine transporter 2

      See identical proteins and their annotated locations for NP_976079.1

      Status: PROVISIONAL

      Source sequence(s)
      L21672
      Related
      ENSRNOP00000043665.4, ENSRNOT00000041950.5
      Conserved Domains (1) summary
      cd11499
      Location:193789
      SLC6sbd_GlyT2; Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      108767245..108833173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275140.1XP_063131210.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

    2. XM_063275124.1XP_063131194.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

    3. XM_063275053.1XP_063131123.1  sodium- and chloride-dependent glycine transporter 2 isoform X1

    4. XM_063275237.1XP_063131307.1  sodium- and chloride-dependent glycine transporter 2 isoform X4

    5. XM_063275070.1XP_063131140.1  sodium- and chloride-dependent glycine transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      F1LNM6, P58295, Q6QDB3
    6. XM_063275456.1XP_063131526.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

    7. XM_063275160.1XP_063131230.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

    8. XM_063275211.1XP_063131281.1  sodium- and chloride-dependent glycine transporter 2 isoform X3

    9. XM_063275413.1XP_063131483.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

    10. XM_063275262.1XP_063131332.1  sodium- and chloride-dependent glycine transporter 2 isoform X5

    11. XM_063275288.1XP_063131358.1  sodium- and chloride-dependent glycine transporter 2 isoform X6

    12. XM_063275351.1XP_063131421.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

    13. XM_063275372.1XP_063131442.1  sodium- and chloride-dependent glycine transporter 2 isoform X7

    14. XM_063275437.1XP_063131507.1  sodium- and chloride-dependent glycine transporter 2 isoform X7