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    KCNG3 potassium voltage-gated channel modifier subfamily G member 3 [ Homo sapiens (human) ]

    Gene ID: 170850, updated on 11-Apr-2024

    Summary

    Official Symbol
    KCNG3provided by HGNC
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 3provided by HGNC
    Primary source
    HGNC:HGNC:18306
    See related
    Ensembl:ENSG00000171126 MIM:606767; AllianceGenome:HGNC:18306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KV6.3; KV10.1
    Summary
    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See KCNG3 in Genome Data Viewer
    Location:
    2p21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (42388352..42493982, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (42393706..42499421, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42669157..42721122, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42396227-42396879 Neighboring gene EML4 antisense RNA 1 Neighboring gene HNF1 motif-containing MPRA enhancer 263/264 Neighboring gene EMAP like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42567158-42568066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42568067-42568974 Neighboring gene H3K27ac hESC enhancers GRCh37_chr2:42587530-42588274 and GRCh37_chr2:42588275-42589018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:42597071-42597572 Neighboring gene cytochrome c oxidase subunit 7A2 like Neighboring gene small nucleolar RNA SNORD75 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42719309-42720066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11406 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42720067-42720824 Neighboring gene Sharpr-MPRA regulatory region 13941 Neighboring gene voltage dependent anion channel 1 pseudogene 13 Neighboring gene ribosomal protein S13 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42752168-42752668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42752669-42753169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:42772737-42773623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42774519-42775024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15649 Neighboring gene metastasis associated 1 family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11407 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42798824-42799350 Neighboring gene uncharacterized LOC105374555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42833249-42834000 Neighboring gene MPRA-validated peak3682 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr2:42881137-42881638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15651 Neighboring gene Sharpr-MPRA regulatory region 10188 Neighboring gene RNA, U6 small nuclear 137, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily G member 3
    Names
    potassium channel, voltage gated modifier subfamily G, member 3
    potassium voltage-gated channel, subfamily G, member 3
    voltage-gated potassium channel 6.3
    voltage-gated potassium channel Kv10.1
    voltage-gated potassium channel subunit Kv10.1
    voltage-gated potassium channel subunit Kv6.3
    voltage-gated potassium channel subunit Kv6.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133329.6NP_579875.1  potassium voltage-gated channel subfamily G member 3 isoform 1

      See identical proteins and their annotated locations for NP_579875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as Kv10.1b, encodes the longer isoform (1).
      Source sequence(s)
      AC025750, AF348982, BC071558
      Consensus CDS
      CCDS1809.1
      UniProtKB/Swiss-Prot
      Q53SC1, Q8TAE7
      Related
      ENSP00000304127.1, ENST00000306078.2
      Conserved Domains (2) summary
      cd18422
      Location:11122
      BTB_POZ_KCNG3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3)
      pfam00520
      Location:219420
      Ion_trans; Ion transport protein
    2. NM_172344.3NP_758847.1  potassium voltage-gated channel subfamily G member 3 isoform 2

      See identical proteins and their annotated locations for NP_758847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as Kv10.1a, lacks an alternate in-frame segment in the coding region, as compared to variant 1. It encodes isoform (2) that lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC025750, AF348982, AF454547, BC071558
      Consensus CDS
      CCDS42674.1
      UniProtKB/Swiss-Prot
      Q8TAE7
      Related
      ENSP00000378424.4, ENST00000394973.4
      Conserved Domains (2) summary
      cd18422
      Location:11122
      BTB_POZ_KCNG3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3)
      pfam00520
      Location:202409
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      42388352..42493982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007069666.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      42393706..42499421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486299.1 RNA Sequence