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    Glmn glomulin, FKBP associated protein [ Mus musculus (house mouse) ]

    Gene ID: 170823, updated on 5-Aug-2018

    Summary

    Official Symbol
    Glmnprovided by MGI
    Official Full Name
    glomulin, FKBP associated proteinprovided by MGI
    Primary source
    MGI:MGI:2141180
    See related
    Ensembl:ENSMUSG00000029276 Vega:OTTMUSG00000023402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fap48; Fap68; AW227515; 9330160J16Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 4.4), CNS E18 (RPKM 3.9) and 20 other tissues See more
    Orthologs

    Genomic context

    See Glmn in Genome Data Viewer
    Location:
    5; 5 E5
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (107548967..107597888, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (107977986..108026907, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 8 Neighboring gene RIKEN cDNA A830010M20 gene Neighboring gene LSM12 homolog pseudogene Neighboring gene RIKEN cDNA 1700028K03 gene Neighboring gene RNA polymerase II associated protein 2 Neighboring gene RIKEN cDNA A930041C12 gene Neighboring gene RIKEN cDNA 4930428O21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6885

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hepatocyte growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-protein transferase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Cul2-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glomulin
    Names
    FAP
    FK506-binding protein-associated protein
    FKBP-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161738.1NP_001155210.1  glomulin isoform a

      See identical proteins and their annotated locations for NP_001155210.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK034160
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q8BZM1
      Related
      ENSMUSP00000080766.2, OTTMUSP00000027362, ENSMUST00000082121.8, OTTMUST00000056836
      Conserved Domains (1) summary
      pfam08568
      Location:1526
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
    2. NM_001161739.1NP_001155211.1  glomulin isoform b

      See identical proteins and their annotated locations for NP_001155211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC117574, AC134411, AK169045
      Consensus CDS
      CCDS51587.1
      UniProtKB/Swiss-Prot
      Q8BZM1
      UniProtKB/TrEMBL
      Q3T9A5
      Related
      ENSMUSP00000098509.3, OTTMUSP00000027733, ENSMUST00000100949.9, OTTMUST00000057490
      Conserved Domains (1) summary
      pfam08568
      Location:1462
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
    3. NM_133248.2NP_573511.2  glomulin isoform a

      See identical proteins and their annotated locations for NP_573511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC134411, AK169045, BY013339
      Consensus CDS
      CCDS19505.1
      UniProtKB/Swiss-Prot
      Q8BZM1
      Related
      ENSMUSP00000077168.6, OTTMUSP00000027361, ENSMUST00000078021.12, OTTMUST00000056835
      Conserved Domains (1) summary
      pfam08568
      Location:1526
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      107548967..107597888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249410.2XP_011247712.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14223
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
    2. XM_006534800.3XP_006534863.1  glomulin isoform X1

      See identical proteins and their annotated locations for XP_006534863.1

      UniProtKB/Swiss-Prot
      Q8BZM1
      Conserved Domains (1) summary
      pfam08568
      Location:1526
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin
    3. XM_017320694.1XP_017176183.1  glomulin isoform X2

      Conserved Domains (1) summary
      pfam08568
      Location:14223
      Kinetochor_Ybp2; uncharacterized protein family, YAP/Alf4/glomulin

    RNA

    1. XR_001784631.1 RNA Sequence

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