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    Usp33 ubiquitin specific peptidase 33 [ Mus musculus (house mouse) ]

    Gene ID: 170822, updated on 23-Jun-2021

    Summary

    Official Symbol
    Usp33provided by MGI
    Official Full Name
    ubiquitin specific peptidase 33provided by MGI
    Primary source
    MGI:MGI:2159711
    See related
    Ensembl:ENSMUSG00000025437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vdu; Vdu1; AA409780; 9830169D19Rik
    Expression
    Broad expression in CNS E18 (RPKM 26.3), CNS E14 (RPKM 24.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Usp33 in Genome Data Viewer
    Location:
    3; 3 H3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (152051797..152099254)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152346184..152393617)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (152009445..152056581)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31999 Neighboring gene VISTA enhancer mm72 Neighboring gene mitoguardin 1 Neighboring gene uncharacterized LOC118568621 Neighboring gene zinc finger, ZZ domain containing 3 Neighboring gene RIKEN cDNA 3110067G11 gene Neighboring gene adenylate kinase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 33
    Names
    VHL-interacting deubiquitinating enzyme 1
    Vhlh-interacting deubiquitinating enzyme 1
    deubiquitinating enzyme 33
    pVHL-interacting deubiquitinating enzyme 1
    ubiquitin specific protease 33
    ubiquitin thioesterase 33
    ubiquitin thiolesterase 33
    ubiquitin-specific-processing protease 33
    NP_001070144.1
    NP_001239415.1
    NP_001342595.1
    NP_573510.2
    XP_030108303.1
    XP_030108304.1
    XP_036018806.1
    XP_036018807.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076676.2NP_001070144.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AA210301, AK082943, AK087467
      Consensus CDS
      CCDS80064.1
      UniProtKB/TrEMBL
      A0A0H2UKB8
      Related
      ENSMUSP00000026507.8, ENSMUST00000026507.13
      Conserved Domains (6) summary
      smart00695
      Location:799879
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:441672
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:155287
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:153671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693762
      DUSP; DUSP domain
    2. NM_001252486.1NP_001239415.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1, resulting in a shorter protein (isoform 3).
      Source sequence(s)
      AA210301, AK087467, AK143844, BC089315
      Consensus CDS
      CCDS57261.1
      UniProtKB/Swiss-Prot
      Q8R5K2
      Related
      ENSMUSP00000113265.4, ENSMUST00000117492.9
      Conserved Domains (6) summary
      smart00695
      Location:799883
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:441672
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:155287
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:153671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693762
      DUSP; DUSP domain
    3. NM_001355666.1NP_001342595.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA210301, AC122529
      Conserved Domains (3) summary
      pfam00443
      Location:154679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701764
      DUSP; DUSP domain
    4. NM_133247.3NP_573510.2  ubiquitin carboxyl-terminal hydrolase 33 isoform 1

      See identical proteins and their annotated locations for NP_573510.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA210301, AK087467, AK143844, BC089315
      Consensus CDS
      CCDS17918.1
      UniProtKB/Swiss-Prot
      Q8R5K2
      Related
      ENSMUSP00000142708.2, ENSMUST00000197748.5
      Conserved Domains (4) summary
      smart00695
      Location:807891
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:154679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701770
      DUSP; DUSP domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      152051797..152099254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162913.1XP_036018806.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

      Conserved Domains (3) summary
      pfam00443
      Location:154679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701770
      DUSP; DUSP domain
    2. XM_036162914.1XP_036018807.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

      Conserved Domains (3) summary
      pfam00443
      Location:154671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693762
      DUSP; DUSP domain
    3. XM_030252444.2XP_030108304.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X4

      Conserved Domains (3) summary
      pfam00443
      Location:154671
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:693756
      DUSP; DUSP domain
    4. XM_030252443.2XP_030108303.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

      Conserved Domains (4) summary
      smart00695
      Location:807891
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:154679
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:3090
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:701770
      DUSP; DUSP domain
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