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    Mtmr4 myotubularin related protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 170749, updated on 27-Jan-2018

    Summary

    Official Symbol
    Mtmr4provided by MGI
    Official Full Name
    myotubularin related protein 4provided by MGI
    Primary source
    MGI:MGI:2180699
    See related
    Ensembl:ENSMUSG00000018401 Vega:OTTMUSG00000001293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM44; ZFYVE11; AA596759; FYVE-DSP2; mKIAA0647
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.2), CNS E18 (RPKM 11.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mtmr4 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (87592135..87616302)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (87405719..87429798)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene testis expressed gene 14 Neighboring gene predicted gene, 34000 Neighboring gene septin 4 Neighboring gene heat shock transcription factor family member 5 Neighboring gene ring finger protein 43 Neighboring gene RIKEN cDNA 1110028F11 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myotubularin-related protein 4
    Names
    FYVE zinc finger phosphatase
    NP_573478.1
    XP_006532446.1
    XP_006532447.1
    XP_006532448.1
    XP_011247082.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357901.1NP_001344830.1  myotubularin-related protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK133861, AK146641, BC058091, BF470538, BY263784, CO041663
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:10491108
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:160496
      Myotub-related; Myotubularin-like phosphatase domain
    2. NM_133215.2NP_573478.1  myotubularin-related protein 4 isoform 1

      See identical proteins and their annotated locations for NP_573478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK133861, AK146641, BC058091, BF470538, BY263784, CO041663
      Consensus CDS
      CCDS25214.1
      UniProtKB/Swiss-Prot
      Q91XS1
      Related
      ENSMUSP00000099468.3, OTTMUSP00000001288, ENSMUST00000103179.9
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:127519
      Myotub-related; Myotubularin-like phosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      87592135..87616302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532384.3XP_006532447.1  myotubularin-related protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006532447.1

      UniProtKB/Swiss-Prot
      Q91XS1
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:127519
      Myotub-related; Myotubularin-like phosphatase domain
    2. XM_006532385.3XP_006532448.1  myotubularin-related protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006532448.1

      UniProtKB/Swiss-Prot
      Q91XS1
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:127519
      Myotub-related; Myotubularin-like phosphatase domain
    3. XM_011248780.2XP_011247082.1  myotubularin-related protein 4 isoform X2

      See identical proteins and their annotated locations for XP_011247082.1

      UniProtKB/Swiss-Prot
      Q91XS1
      Related
      ENSMUSP00000112902.1, OTTMUSP00000001290, ENSMUST00000119628.7, OTTMUST00000002598
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:127519
      Myotub-related; Myotubularin-like phosphatase domain
    4. XM_006532383.2XP_006532446.1  myotubularin-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006532446.1

      Conserved Domains (3) summary
      cd13342
      Location:37150
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11201179
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:141533
      Myotub-related; Myotubularin-like phosphatase domain

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187003.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      717786..741867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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