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    Mtmr4 myotubularin related protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 170749, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mtmr4provided by MGI
    Official Full Name
    myotubularin related protein 4provided by MGI
    Primary source
    MGI:MGI:2180699
    See related
    Ensembl:ENSMUSG00000018401 AllianceGenome:MGI:2180699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM44; ZFYVE11; FYVE-DSP2; mKIAA0647
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; and protein phosphatase binding activity. Predicted to be involved in phosphatidylinositol dephosphorylation; regulation of autophagy; and regulation of phosphatidylinositol dephosphorylation. Predicted to be located in endosome. Predicted to be active in cytoplasm and membrane. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human MTMR4 (myotubularin related protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.2), CNS E18 (RPKM 11.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtmr4 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87482780..87507128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87591954..87616302)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 14 Neighboring gene predicted gene, 34000 Neighboring gene septin 4 Neighboring gene heat shock transcription factor family member 5 Neighboring gene ring finger protein 43 Neighboring gene predicted gene, 25968

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    myotubularin-related protein 4
    Names
    FYVE zinc finger phosphatase
    NP_001344830.1
    NP_573478.1
    XP_006532446.1
    XP_006532447.1
    XP_006532448.1
    XP_011247082.1
    XP_030101475.1
    XP_030101476.1
    XP_036012263.1
    XP_036012264.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357901.1NP_001344830.1  myotubularin-related protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK133861, AK146641, BC058091, BF470538, BY263784, CO041663
      Consensus CDS
      CCDS88215.1
      Related
      ENSMUSP00000090478.6, ENSMUST00000092802.12
      Conserved Domains (3) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:10491108
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      pfam06602
      Location:160496
      Myotub-related; Myotubularin-like phosphatase domain
    2. NM_001402585.1NP_001389514.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    3. NM_001402586.1NP_001389515.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    4. NM_001402587.1NP_001389516.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    5. NM_001402588.1NP_001389517.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    6. NM_001402589.1NP_001389518.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    7. NM_001402590.1NP_001389519.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    8. NM_001402591.1NP_001389520.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    9. NM_001402592.1NP_001389521.1  myotubularin-related protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596086
      UniProtKB/Swiss-Prot
      Q5ND08
    10. NM_001402593.1NP_001389522.1  myotubularin-related protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596086
    11. NM_001402594.1NP_001389523.1  myotubularin-related protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596086
    12. NM_133215.2NP_573478.1  myotubularin-related protein 4 isoform 1

      See identical proteins and their annotated locations for NP_573478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK133861, AK146641, BC058091, BF470538, BY263784, CO041663
      Consensus CDS
      CCDS25214.1
      UniProtKB/Swiss-Prot
      Q5ND08, Q91XS1
      Related
      ENSMUSP00000099468.4, ENSMUST00000103179.10
      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87482780..87507128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245616.1XP_030101476.1  myotubularin-related protein 4 isoform X2

      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family
    2. XM_006532384.5XP_006532447.1  myotubularin-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q91XS1
      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family
    3. XM_036156371.1XP_036012264.1  myotubularin-related protein 4 isoform X3

      Conserved Domains (3) summary
      cd15733
      Location:10761135
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:142449
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      cl17171
      Location:2106
      PH-like; Pleckstrin homology-like domain
    4. XM_006532385.5XP_006532448.1  myotubularin-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q91XS1
      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family
    5. XM_011248780.4XP_011247082.1  myotubularin-related protein 4 isoform X2

      UniProtKB/Swiss-Prot
      Q91XS1
      Related
      ENSMUSP00000112902.2, ENSMUST00000119628.8
      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family
    6. XM_030245615.2XP_030101475.1  myotubularin-related protein 4 isoform X2

      Conserved Domains (4) summary
      cd13342
      Location:23136
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11061165
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:172479
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:729849
      Atrophin-1; Atrophin-1 family
    7. XM_036156370.1XP_036012263.1  myotubularin-related protein 4 isoform X3

      Conserved Domains (3) summary
      cd15733
      Location:10761135
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:142449
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      cl17171
      Location:2106
      PH-like; Pleckstrin homology-like domain
    8. XM_006532383.3XP_006532446.1  myotubularin-related protein 4 isoform X1

      Conserved Domains (4) summary
      cd13342
      Location:37150
      PH-GRAM_MTMR4; Myotubularian (MTM) related 4 protein (MTMR4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15733
      Location:11201179
      FYVE_MTMR4; FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins
      cd14587
      Location:186493
      PTP-MTMR4; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 4
      pfam03154
      Location:743863
      Atrophin-1; Atrophin-1 family