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    Oxr1 oxidation resistance 1 [ Mus musculus (house mouse) ]

    Gene ID: 170719, updated on 13-May-2018

    Summary

    Official Symbol
    Oxr1provided by MGI
    Official Full Name
    oxidation resistance 1provided by MGI
    Primary source
    MGI:MGI:2179326
    See related
    Ensembl:ENSMUSG00000022307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C7; C7B; 2210416C20Rik
    Expression
    Broad expression in frontal lobe adult (RPKM 11.8), cerebellum adult (RPKM 10.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See Oxr1 in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (41447425..41861051)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (41279028..41692594)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33557 Neighboring gene predicted gene, 41312 Neighboring gene actin-binding Rho activating protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC103081, MGC107466

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    oxidation resistance protein 1
    Names
    nucleolar protein C7
    protein C7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130163.1NP_001123635.1  oxidation resistance protein 1 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform B) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AC129212, AF324899, AF333985, AK158703
      Consensus CDS
      CCDS49600.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000087553.5, ENSMUST00000090095.12
      Conserved Domains (3) summary
      smart00584
      Location:589751
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:1254
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:1254
      LysM; LysM domain
    2. NM_001130164.1NP_001123636.1  oxidation resistance protein 1 isoform C

      See identical proteins and their annotated locations for NP_001123636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform C) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AF333985, AK158703, AW106090, BK006239
      Consensus CDS
      CCDS49601.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      UniProtKB/TrEMBL
      B1H3M0
      Related
      ENSMUSP00000130456.1, ENSMUST00000166917.2
      Conserved Domains (1) summary
      smart00584
      Location:54216
      TLDc; domain in TBC and LysM domain containing proteins
    3. NM_001130165.1NP_001123637.1  oxidation resistance protein 1 isoform D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform D) with a shorter, distinct N-terminus and a missing region in the C-terminus, compared to isoform E.
      Source sequence(s)
      AF324899, AF333985, AK158703, CJ178211
      Consensus CDS
      CCDS49599.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      UniProtKB/TrEMBL
      E9Q0A7
      Related
      ENSMUSP00000126266.1, ENSMUST00000170127.8
      Conserved Domains (3) summary
      smart00584
      Location:670832
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:52135
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:93135
      LysM; LysM domain
    4. NM_001130166.1NP_001123638.1  oxidation resistance protein 1 isoform E

      See identical proteins and their annotated locations for NP_001123638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (E). Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AF333985, AK158703, BE988908
      Consensus CDS
      CCDS49598.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000105926.2, ENSMUST00000110297.9
      Conserved Domains (3) summary
      smart00584
      Location:704866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100142
      LysM; LysM domain
      cl26761
      Location:265549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    5. NM_001358976.1NP_001345905.1  oxidation resistance protein 1 isoform F

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 5. The encoded isoform (F) has a distinct N-terminus and is shorter than isoform E.
      Source sequence(s)
      AC129212
      Conserved Domains (3) summary
      smart00584
      Location:697859
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:93135
      LysM; LysM domain
      pfam09726
      Location:257540
      Macoilin; Transmembrane protein
    6. NM_001358977.1NP_001345906.1  oxidation resistance protein 1 isoform E

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 5. Variants 5 and 7 encode the same protein.
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633
      Conserved Domains (3) summary
      smart00584
      Location:704866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100142
      LysM; LysM domain
      cl26761
      Location:265549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    7. NM_001358978.1NP_001345907.1  oxidation resistance protein 1 isoform G

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an exon in the coding region, compared to variant 1. The encoded isoform (G) is shorter, compared to isoform E.
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633
      Conserved Domains (3) summary
      smart00584
      Location:677839
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100142
      LysM; LysM domain
      cl26761
      Location:265549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    8. NM_130885.2NP_570955.1  oxidation resistance protein 1 isoform A

      See identical proteins and their annotated locations for NP_570955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region and 5' UTR, compared to variant 5, resulting in a protein (isoform A) with a shorter and distinct N-terminus, compared to isoform E.
      Source sequence(s)
      AC129212
      Consensus CDS
      CCDS27448.1
      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000022918.7, ENSMUST00000022918.14
      Conserved Domains (3) summary
      smart00584
      Location:616778
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:1254
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:1254
      LysM; LysM domain

    RNA

    1. NR_152565.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains an alternate internal exon, compared to variant 5. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC118590, AC129212, AC141481, AC164633

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      41447425..41861051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316491.1XP_017171980.1  oxidation resistance protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q4KMM3
      Related
      ENSMUSP00000155237.1, ENSMUST00000230203.1
      Conserved Domains (3) summary
      smart00584
      Location:677839
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100142
      LysM; LysM domain
      cl26761
      Location:265549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    2. XM_017316490.1XP_017171979.1  oxidation resistance protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q4KMM3
      Conserved Domains (3) summary
      smart00584
      Location:704866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100142
      LysM; LysM domain
      cl26761
      Location:265549
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    3. XM_006520527.2XP_006520590.1  oxidation resistance protein 1 isoform X5

      Conserved Domains (3) summary
      smart00584
      Location:635797
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:473
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:3173
      LysM; LysM domain
    4. XM_006520526.3XP_006520589.1  oxidation resistance protein 1 isoform X4

      Conserved Domains (3) summary
      smart00584
      Location:637799
      TLDc; domain in TBC and LysM domain containing proteins
      COG1388
      Location:3375
      LysM; LysM repeat [Cell wall/membrane/envelope biogenesis]
      pfam01476
      Location:3375
      LysM; LysM domain
    5. XM_006520524.3XP_006520587.1  oxidation resistance protein 1 isoform X2

      Conserved Domains (3) summary
      smart00584
      Location:697859
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:93135
      LysM; LysM domain
      pfam09726
      Location:257540
      Macoilin; Transmembrane protein
    6. XM_006520531.3XP_006520594.1  oxidation resistance protein 1 isoform X6

      Related
      ENSMUSP00000155424.1, ENSMUST00000230131.1
      Conserved Domains (1) summary
      smart00584
      Location:81243
      TLDc; domain in TBC and LysM domain containing proteins

    RNA

    1. XR_001781502.1 RNA Sequence

    2. XR_001781501.1 RNA Sequence

    3. XR_001781500.1 RNA Sequence

    4. XR_001781499.1 RNA Sequence

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