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    Recql5 RecQ protein-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 170472, updated on 24-Apr-2022

    Summary

    Official Symbol
    Recql5provided by MGI
    Official Full Name
    RecQ protein-like 5provided by MGI
    Primary source
    MGI:MGI:2156841
    See related
    Ensembl:ENSMUSG00000020752 AllianceGenome:MGI:2156841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RecQ5; Recq5b; Recql5b
    Summary
    Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II, holoenzyme. Predicted to be active in chromosome and cytoplasm. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.0), large intestine adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Recql5 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115783421..115824339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115892595..115933514, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115753991..115794320, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL2 scribble cell polarity complex component Neighboring gene myosin XVB Neighboring gene small integral membrane protein 5 Neighboring gene small integral membrane protein 6 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to camptothecin IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to camptothecin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, holoenzyme ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent DNA helicase Q5
    Names
    DNA helicase, RecQ-like type 5
    RECQL5beta
    NP_569721.1
    XP_006532421.1
    XP_006532422.1
    XP_006532424.1
    XP_006532425.1
    XP_006532426.1
    XP_030101474.1
    XP_036012259.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130454.2NP_569721.1  ATP-dependent DNA helicase Q5

      See identical proteins and their annotated locations for NP_569721.1

      Status: VALIDATED

      Source sequence(s)
      AK049269, AL645647, AW049927, BC059000
      Consensus CDS
      CCDS25650.1
      UniProtKB/Swiss-Prot
      Q8VID5
      Related
      ENSMUSP00000021097.4, ENSMUST00000021097.10
      Conserved Domains (2) summary
      COG0514
      Location:15439
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:626817
      RecQ5; RecQ helicase protein-like 5 (RecQ5)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115783421..115824339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532361.5XP_006532424.1  ATP-dependent DNA helicase Q5 isoform X4

      See identical proteins and their annotated locations for XP_006532424.1

      Conserved Domains (2) summary
      COG0514
      Location:1133
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:320508
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
    2. XM_006532359.5XP_006532422.1  ATP-dependent DNA helicase Q5 isoform X3

      Conserved Domains (2) summary
      COG0514
      Location:6398
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:585773
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
    3. XM_006532358.5XP_006532421.1  ATP-dependent DNA helicase Q5 isoform X1

      Conserved Domains (2) summary
      COG0514
      Location:16440
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:627815
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
    4. XM_036156366.1XP_036012259.1  ATP-dependent DNA helicase Q5 isoform X2

      Conserved Domains (2) summary
      COG0514
      Location:15439
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]
      pfam06959
      Location:626817
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
    5. XM_006532363.5XP_006532426.1  ATP-dependent DNA helicase Q5 isoform X6

      Conserved Domains (2) summary
      pfam06959
      Location:231419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:1740
      RecQ_Zn_bind; RecQ zinc-binding
    6. XM_006532362.4XP_006532425.1  ATP-dependent DNA helicase Q5 isoform X5

      Conserved Domains (2) summary
      pfam06959
      Location:231419
      RecQ5; RecQ helicase protein-like 5 (RecQ5)
      pfam16124
      Location:1240
      RecQ_Zn_bind; RecQ zinc-binding
    7. XM_030245614.2XP_030101474.1  ATP-dependent DNA helicase Q5 isoform X7

      Conserved Domains (1) summary
      COG0514
      Location:16440
      RecQ; Superfamily II DNA helicase RecQ [Replication, recombination and repair]

    RNA

    1. XR_003949325.2 RNA Sequence

    2. XR_003949327.2 RNA Sequence

    3. XR_003949326.2 RNA Sequence