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    Lss lanosterol synthase [ Mus musculus (house mouse) ]

    Gene ID: 16987, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lssprovided by MGI
    Official Full Name
    lanosterol synthaseprovided by MGI
    Primary source
    MGI:MGI:1336155
    See related
    Ensembl:ENSMUSG00000033105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    O; Osc; D10Ertd116; D10Ertd116e; 2810025N20Rik
    Summary
    This gene encodes an enzyme that catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in liver E18 (RPKM 29.4), liver E14.5 (RPKM 13.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Lss in Genome Data Viewer
    Location:
    10 C1; 10 39.1 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76367303..76392973)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76531565..76557139)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75994372..76016679)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene ybeY metallopeptidase Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene RIKEN cDNA 4930483K19 gene Neighboring gene spermatogenesis and centriole associated 1 like Neighboring gene predicted gene 15343 Neighboring gene formiminotransferase cyclodeaminase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27893

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-amyrin synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables intramolecular transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lanosterol synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lanosterol synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lanosterol synthase
    Names
    2,3-epoxysqualene--lanosterol cyclase
    oxidosqualene--lanosterol cyclase
    NP_666118.1
    XP_006513347.1
    XP_030100782.1
    XP_036011544.1
    XP_036011545.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146006.2NP_666118.1  lanosterol synthase

      See identical proteins and their annotated locations for NP_666118.1

      Status: REVIEWED

      Source sequence(s)
      AK014742, AK031271, AK078023, AK141216, AK147680, BY474863, CJ128932
      Consensus CDS
      CCDS23948.1
      UniProtKB/Swiss-Prot
      Q8BLN5
      Related
      ENSMUSP00000046856.7, ENSMUST00000048678.7
      Conserved Domains (2) summary
      cd02892
      Location:78720
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
      TIGR01787
      Location:77722
      squalene_cyclas; squalene/oxidosqualene cyclases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76367303..76392973
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155651.1XP_036011544.1  lanosterol synthase isoform X1

      Conserved Domains (1) summary
      TIGR01787
      Location:1595
      squalene_cyclas; squalene/oxidosqualene cyclases
    2. XM_006513284.4XP_006513347.1  lanosterol synthase isoform X2

      Conserved Domains (1) summary
      TIGR01787
      Location:77523
      squalene_cyclas; squalene/oxidosqualene cyclases
    3. XM_036155652.1XP_036011545.1  lanosterol synthase isoform X3

      Conserved Domains (1) summary
      TIGR01787
      Location:1507
      squalene_cyclas; squalene/oxidosqualene cyclases
    4. XM_030244922.2XP_030100782.1  lanosterol synthase isoform X3

      Related
      ENSMUST00000160671.8
      Conserved Domains (1) summary
      TIGR01787
      Location:1507
      squalene_cyclas; squalene/oxidosqualene cyclases

    RNA

    1. XR_004936110.1 RNA Sequence

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