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    Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16978, updated on 21-Oct-2021

    Summary

    Official Symbol
    Lrrfip1provided by MGI
    Official Full Name
    leucine rich repeat (in FLII) interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1342770
    See related
    Ensembl:ENSMUSG00000026305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fliiap1; AU024550
    Expression
    Ubiquitous expression in bladder adult (RPKM 22.2), placenta adult (RPKM 10.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrrfip1 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90924652..91056666)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90996930..91128944)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (92895304..93025521)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone Neighboring gene RAB17, member RAS oncogene family Neighboring gene predicted gene, 35443 Neighboring gene RNA binding motif protein 44 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat flightless-interacting protein 1
    Names
    FLAP (FLI LRR associated protein)
    FLI-LRR-associated protein 1
    H186 FLAP
    LRR FLII-interacting protein 1
    flap-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111311.1NP_001104781.1  leucine-rich repeat flightless-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001104781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK077637, AK134120, AK162191, AV024479, BB709810
      Consensus CDS
      CCDS48320.1
      UniProtKB/Swiss-Prot
      Q3UZ39
      Related
      ENSMUSP00000095254.4, ENSMUST00000097649.10
      Conserved Domains (1) summary
      pfam09738
      Location:42258
      DUF2051; Double stranded RNA binding protein (DUF2051)
    2. NM_001111312.1NP_001104782.1  leucine-rich repeat flightless-interacting protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001104782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region and contains different segments for both UTRs, compared to variant 1. The resulting protein (isoform 3) is shorter and has distinct N- and C-termini when it is compared to isoform 1.
      Source sequence(s)
      AF045573, AI452149, AK041162, BC145642, CJ154753
      Consensus CDS
      CCDS48319.1
      UniProtKB/Swiss-Prot
      Q3UZ39
      UniProtKB/TrEMBL
      A6H5U5, G5E8E1, Q8BLV4
      Related
      ENSMUSP00000065850.7, ENSMUST00000068116.13
      Conserved Domains (1) summary
      pfam09738
      Location:52352
      DUF2051; Double stranded RNA binding protein (DUF2051)
    3. NM_001310732.1NP_001297661.1  leucine-rich repeat flightless-interacting protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 3' UTR and in the coding region, but maintains the reading frame compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks several internal segments compared to isoform 1.
      Source sequence(s)
      AC162883
      Consensus CDS
      CCDS78647.1
      UniProtKB/TrEMBL
      A0A087WPK3
      Related
      ENSMUSP00000139811.2, ENSMUST00000189617.3
      Conserved Domains (2) summary
      COG1340
      Location:385655
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cl12057
      Location:385463
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
    4. NM_008515.4NP_032541.1  leucine-rich repeat flightless-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_032541.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region and contains a different 3' UTR, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AF045573, AI452149, AK077637, BC145642, BY739242
      Consensus CDS
      CCDS35662.1
      UniProtKB/Swiss-Prot
      Q3UZ39
      UniProtKB/TrEMBL
      A6H5U5
      Related
      ENSMUSP00000095255.4, ENSMUST00000097650.10
      Conserved Domains (1) summary
      COG1340
      Location:350620
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      90924652..91056666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529209.4XP_006529272.1  leucine-rich repeat flightless-interacting protein 1 isoform X1

      Related
      ENSMUSP00000139497.2, ENSMUST00000185531.7
      Conserved Domains (3) summary
      TIGR04211
      Location:398486
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:260613
      LRRFIP; LRRFIP family
      pfam11932
      Location:629688
      DUF3450; Protein of unknown function (DUF3450)
    2. XM_017318960.2XP_017174449.1  leucine-rich repeat flightless-interacting protein 1 isoform X3

      Conserved Domains (2) summary
      pfam09738
      Location:260582
      LRRFIP; LRRFIP family
      pfam11932
      Location:598657
      DUF3450; Protein of unknown function (DUF3450)
    3. XM_017318958.2XP_017174447.1  leucine-rich repeat flightless-interacting protein 1 isoform X2

      Conserved Domains (3) summary
      TIGR04211
      Location:374462
      SH3_and_anchor; SH3 domain protein
      pfam09738
      Location:260589
      LRRFIP; LRRFIP family
      pfam11932
      Location:605664
      DUF3450; Protein of unknown function (DUF3450)
    4. XM_017318961.2XP_017174450.1  leucine-rich repeat flightless-interacting protein 1 isoform X4

      Conserved Domains (2) summary
      pfam09738
      Location:245574
      LRRFIP; LRRFIP family
      pfam11932
      Location:590649
      DUF3450; Protein of unknown function (DUF3450)
    5. XM_017318969.2XP_017174458.1  leucine-rich repeat flightless-interacting protein 1 isoform X5

      Conserved Domains (2) summary
      pfam09738
      Location:223552
      LRRFIP; LRRFIP family
      pfam11932
      Location:568627
      DUF3450; Protein of unknown function (DUF3450)
    6. XM_017318974.2XP_017174463.1  leucine-rich repeat flightless-interacting protein 1 isoform X6

      Conserved Domains (2) summary
      pfam09738
      Location:197526
      LRRFIP; LRRFIP family
      pfam11932
      Location:542601
      DUF3450; Protein of unknown function (DUF3450)
    7. XM_017318999.2XP_017174488.1  leucine-rich repeat flightless-interacting protein 1 isoform X9

      Conserved Domains (2) summary
      pfam09738
      Location:197495
      LRRFIP; LRRFIP family
      pfam11932
      Location:511570
      DUF3450; Protein of unknown function (DUF3450)
    8. XM_017319017.2XP_017174506.1  leucine-rich repeat flightless-interacting protein 1 isoform X14

      Conserved Domains (2) summary
      pfam09738
      Location:197464
      LRRFIP; LRRFIP family
      pfam11932
      Location:480539
      DUF3450; Protein of unknown function (DUF3450)
    9. XM_036162412.1XP_036018305.1  leucine-rich repeat flightless-interacting protein 1 isoform X13

      Conserved Domains (2) summary
      pfam09738
      Location:175466
      LRRFIP; LRRFIP family
      pfam11932
      Location:482541
      DUF3450; Protein of unknown function (DUF3450)
    10. XM_017318996.2XP_017174485.1  leucine-rich repeat flightless-interacting protein 1 isoform X8

      Conserved Domains (2) summary
      pfam09738
      Location:175504
      LRRFIP; LRRFIP family
      pfam11932
      Location:520579
      DUF3450; Protein of unknown function (DUF3450)
    11. XM_017319004.2XP_017174493.1  leucine-rich repeat flightless-interacting protein 1 isoform X12

      Conserved Domains (2) summary
      pfam09738
      Location:175473
      LRRFIP; LRRFIP family
      pfam11932
      Location:489548
      DUF3450; Protein of unknown function (DUF3450)
    12. XM_036162414.1XP_036018307.1  leucine-rich repeat flightless-interacting protein 1 isoform X16

      Conserved Domains (2) summary
      pfam09738
      Location:175442
      LRRFIP; LRRFIP family
      pfam11932
      Location:458517
      DUF3450; Protein of unknown function (DUF3450)
    13. XM_036162407.1XP_036018300.1  leucine-rich repeat flightless-interacting protein 1 isoform X7

      Conserved Domains (2) summary
      pfam09738
      Location:184513
      LRRFIP; LRRFIP family
      pfam11932
      Location:529588
      DUF3450; Protein of unknown function (DUF3450)
    14. XM_036162413.1XP_036018306.1  leucine-rich repeat flightless-interacting protein 1 isoform X15

      Conserved Domains (2) summary
      pfam09738
      Location:162453
      LRRFIP; LRRFIP family
      pfam11932
      Location:469528
      DUF3450; Protein of unknown function (DUF3450)
    15. XM_017319000.2XP_017174489.1  leucine-rich repeat flightless-interacting protein 1 isoform X10

      Conserved Domains (2) summary
      pfam09738
      Location:162491
      LRRFIP; LRRFIP family
      pfam11932
      Location:507566
      DUF3450; Protein of unknown function (DUF3450)
    16. XM_036162428.1XP_036018321.1  leucine-rich repeat flightless-interacting protein 1 isoform X23

      Conserved Domains (2) summary
      pfam09738
      Location:52375
      LRRFIP; LRRFIP family
      pfam11932
      Location:391450
      DUF3450; Protein of unknown function (DUF3450)
    17. XM_030251813.1XP_030107673.1  leucine-rich repeat flightless-interacting protein 1 isoform X22

      Conserved Domains (2) summary
      pfam09738
      Location:52379
      LRRFIP; LRRFIP family
      pfam11932
      Location:395454
      DUF3450; Protein of unknown function (DUF3450)
    18. XM_030251811.1XP_030107671.1  leucine-rich repeat flightless-interacting protein 1 isoform X17

      Conserved Domains (2) summary
      pfam09738
      Location:52417
      LRRFIP; LRRFIP family
      pfam11932
      Location:433492
      DUF3450; Protein of unknown function (DUF3450)
    19. XM_030251812.1XP_030107672.1  leucine-rich repeat flightless-interacting protein 1 isoform X20

      Conserved Domains (2) summary
      pfam09738
      Location:52386
      LRRFIP; LRRFIP family
      pfam11932
      Location:402461
      DUF3450; Protein of unknown function (DUF3450)
    20. XM_030251816.1XP_030107676.1  leucine-rich repeat flightless-interacting protein 1 isoform X25

      Conserved Domains (2) summary
      pfam09738
      Location:52355
      LRRFIP; LRRFIP family
      pfam11932
      Location:371430
      DUF3450; Protein of unknown function (DUF3450)
    21. XM_030251823.1XP_030107683.1  leucine-rich repeat flightless-interacting protein 1 isoform X32

      Conserved Domains (2) summary
      pfam09738
      Location:52415
      LRRFIP; LRRFIP family
      pfam11932
      Location:431490
      DUF3450; Protein of unknown function (DUF3450)
    22. XM_030251821.1XP_030107681.1  leucine-rich repeat flightless-interacting protein 1 isoform X31

      Conserved Domains (2) summary
      pfam09738
      Location:52384
      LRRFIP; LRRFIP family
      pfam11932
      Location:400459
      DUF3450; Protein of unknown function (DUF3450)
    23. XM_030251824.1XP_030107684.1  leucine-rich repeat flightless-interacting protein 1 isoform X33

      Conserved Domains (2) summary
      pfam09738
      Location:52391
      LRRFIP; LRRFIP family
      pfam11932
      Location:407466
      DUF3450; Protein of unknown function (DUF3450)
    24. XM_030251814.1XP_030107674.1  leucine-rich repeat flightless-interacting protein 1 isoform X24

      Conserved Domains (2) summary
      pfam09738
      Location:52360
      LRRFIP; LRRFIP family
      pfam11932
      Location:376435
      DUF3450; Protein of unknown function (DUF3450)
    25. XM_006529216.3XP_006529279.1  leucine-rich repeat flightless-interacting protein 1 isoform X29

      See identical proteins and their annotated locations for XP_006529279.1

      Conserved Domains (2) summary
      pfam09738
      Location:52329
      LRRFIP; LRRFIP family
      pfam11932
      Location:345404
      DUF3450; Protein of unknown function (DUF3450)
    26. XM_036162410.1XP_036018303.1  leucine-rich repeat flightless-interacting protein 1 isoform X11

      Conserved Domains (2) summary
      pfam09738
      Location:152481
      LRRFIP; LRRFIP family
      pfam11932
      Location:497556
      DUF3450; Protein of unknown function (DUF3450)
    27. XM_036162419.1XP_036018312.1  leucine-rich repeat flightless-interacting protein 1 isoform X19

      Conserved Domains (2) summary
      pfam09738
      Location:98396
      LRRFIP; LRRFIP family
      pfam11932
      Location:412471
      DUF3450; Protein of unknown function (DUF3450)
    28. XM_036162433.1XP_036018326.1  leucine-rich repeat flightless-interacting protein 1 isoform X27

      Conserved Domains (2) summary
      pfam09738
      Location:42345
      LRRFIP; LRRFIP family
      pfam11932
      Location:361420
      DUF3450; Protein of unknown function (DUF3450)
    29. XM_036162434.1XP_036018327.1  leucine-rich repeat flightless-interacting protein 1 isoform X28

      Conserved Domains (2) summary
      pfam09738
      Location:42343
      LRRFIP; LRRFIP family
      pfam11932
      Location:359418
      DUF3450; Protein of unknown function (DUF3450)
    30. XM_006529214.2XP_006529277.1  leucine-rich repeat flightless-interacting protein 1 isoform X21

      See identical proteins and their annotated locations for XP_006529277.1

      Conserved Domains (2) summary
      pfam09738
      Location:42381
      LRRFIP; LRRFIP family
      pfam11932
      Location:397456
      DUF3450; Protein of unknown function (DUF3450)
    31. XM_036162432.1XP_036018325.1  leucine-rich repeat flightless-interacting protein 1 isoform X26

      Conserved Domains (2) summary
      pfam09738
      Location:42350
      LRRFIP; LRRFIP family
      pfam11932
      Location:366425
      DUF3450; Protein of unknown function (DUF3450)
    32. XM_006529215.2XP_006529278.1  leucine-rich repeat flightless-interacting protein 1 isoform X30

      Conserved Domains (2) summary
      pfam09738
      Location:42319
      LRRFIP; LRRFIP family
      pfam11932
      Location:335394
      DUF3450; Protein of unknown function (DUF3450)
    33. XM_036162418.1XP_036018311.1  leucine-rich repeat flightless-interacting protein 1 isoform X18

      Conserved Domains (2) summary
      pfam09738
      Location:47400
      LRRFIP; LRRFIP family
      pfam11932
      Location:416475
      DUF3450; Protein of unknown function (DUF3450)

    RNA

    1. XR_004940657.1 RNA Sequence

    2. XR_004940659.1 RNA Sequence

    3. XR_004940661.1 RNA Sequence

    4. XR_004940660.1 RNA Sequence

    5. XR_004940663.1 RNA Sequence

    6. XR_004940664.1 RNA Sequence

    7. XR_004940667.1 RNA Sequence

    8. XR_004940666.1 RNA Sequence

    9. XR_004940670.1 RNA Sequence

    10. XR_004940665.1 RNA Sequence

    11. XR_004940669.1 RNA Sequence

    12. XR_004940668.1 RNA Sequence

    13. XR_004940658.1 RNA Sequence

    14. XR_004940662.1 RNA Sequence

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