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    Lpl lipoprotein lipase [ Mus musculus (house mouse) ]

    Gene ID: 16956, updated on 8-Dec-2018

    Summary

    Official Symbol
    Lplprovided by MGI
    Official Full Name
    lipoprotein lipaseprovided by MGI
    Primary source
    MGI:MGI:96820
    See related
    Ensembl:ENSMUSG00000015568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 870.9), genital fat pad adult (RPKM 464.3) and 3 other tissues See more
    Orthologs

    Genomic context

    See Lpl in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (68880555..68906932)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (71404454..71430831)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene integrator complex subunit 10 Neighboring gene predicted gene, 32997 Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride binding ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    low-density lipoprotein particle mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage derived foam cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chylomicron IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    very-low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    lipoprotein lipase
    Names
    O 1-4-5
    NP_032535.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008509.2NP_032535.2  lipoprotein lipase precursor

      See identical proteins and their annotated locations for NP_032535.2

      Status: VALIDATED

      Source sequence(s)
      AC158236, AK150375, AK152014
      Consensus CDS
      CCDS40357.1
      UniProtKB/Swiss-Prot
      P11152
      Related
      ENSMUSP00000015712.7, ENSMUST00000015712.14
      Conserved Domains (3) summary
      TIGR03230
      Location:33472
      lipo_lipase; lipoprotein lipase
      cd00707
      Location:37334
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      cd01758
      Location:341465
      PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      68880555..68906932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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