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    Sh2b3 SH2B adaptor protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 16923, updated on 22-Aug-2021

    Summary

    Official Symbol
    Sh2b3provided by MGI
    Official Full Name
    SH2B adaptor protein 3provided by MGI
    Primary source
    MGI:MGI:893598
    See related
    Ensembl:ENSMUSG00000042594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; Lnk; AI429800
    Summary
    This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in spleen adult (RPKM 35.7), testis adult (RPKM 30.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sh2b3 in Genome Data Viewer
    Location:
    5 F; 5 61.99 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121953544..121975706, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121815481..121837645, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122267224..122286810, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene microRNA 7031 Neighboring gene predicted gene, 32422 Neighboring gene PH domain containing endocytic trafficking adaptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor complex adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables stem cell factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect cellular response to chemokine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interleukin-3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of Kit signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of platelet aggregation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect thrombopoietin-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in thrombopoietin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect thrombopoietin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    SH2B adapter protein 3
    Names
    linker of T-cell receptor pathways
    lymphocyte-specific adapter protein Lnk
    signal transduction protein Lnk

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306126.1NP_001293055.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001293055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000113926.2, ENSMUST00000122426.8
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    2. NM_001306127.1NP_001293056.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001293056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000083490.2, ENSMUST00000086310.8
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    3. NM_001306128.1NP_001293057.1  SH2B adapter protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS84952.1
      UniProtKB/TrEMBL
      D3Z3Y5
      Related
      ENSMUSP00000113808.2, ENSMUST00000118580.6
      Conserved Domains (3) summary
      cd10412
      Location:317413
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    4. NM_008507.4NP_032533.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_032533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000041611.8, ENSMUST00000040308.14
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121953544..121975706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530171.5XP_006530234.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530234.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    2. XM_036164833.1XP_036020726.1  SH2B adapter protein 3 isoform X1

      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    3. XM_006530173.5XP_006530236.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530236.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    4. XM_006530172.1XP_006530235.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530235.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    5. XM_006530170.5XP_006530233.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530233.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
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