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    Sh2b3 SH2B adaptor protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 16923, updated on 23-May-2018

    Summary

    Official Symbol
    Sh2b3provided by MGI
    Official Full Name
    SH2B adaptor protein 3provided by MGI
    Primary source
    MGI:MGI:893598
    See related
    Ensembl:ENSMUSG00000042594 Vega:OTTMUSG00000029807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lnk; AI429800
    Summary
    This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in spleen adult (RPKM 35.7), testis adult (RPKM 30.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sh2b3 in Genome Data Viewer
    Location:
    5 F; 5 61.99 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (121815481..121837650, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (122267224..122286810, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene BRCA1 associated protein Neighboring gene ataxin 2 Neighboring gene microRNA 7031 Neighboring gene predicted gene, 32422 Neighboring gene PH domain containing endocytic trafficking adaptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    SH2B adapter protein 3
    Names
    linker of T-cell receptor pathways
    lymphocyte-specific adapter protein Lnk
    signal transduction protein Lnk

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306126.1NP_001293055.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001293055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000113926.1, OTTMUSP00000038371, ENSMUST00000122426.7, OTTMUST00000073991
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    2. NM_001306127.1NP_001293056.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001293056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000083490.1, OTTMUSP00000038367, ENSMUST00000086310.7, OTTMUST00000073987
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    3. NM_001306128.1NP_001293057.1  SH2B adapter protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS84952.1
      UniProtKB/TrEMBL
      D3Z3Y5
      Related
      ENSMUSP00000113808.1, OTTMUSP00000038370, ENSMUST00000118580.5, OTTMUST00000073990
      Conserved Domains (3) summary
      cd10412
      Location:317413
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    4. NM_008507.4NP_032533.1  SH2B adapter protein 3 isoform 1

      See identical proteins and their annotated locations for NP_032533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC113302, AK028796, BP762530
      Consensus CDS
      CCDS19641.1
      UniProtKB/Swiss-Prot
      O09039
      Related
      ENSMUSP00000041611.7, OTTMUSP00000038368, ENSMUST00000040308.13, OTTMUST00000073988
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      121815481..121837650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530171.3XP_006530234.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530234.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    2. XM_006530173.3XP_006530236.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530236.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    3. XM_006530172.1XP_006530235.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530235.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
    4. XM_006530170.3XP_006530233.1  SH2B adapter protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006530233.1

      UniProtKB/Swiss-Prot
      O09039
      Conserved Domains (3) summary
      cd10412
      Location:327423
      SH2_SH2B3; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
      cd01231
      Location:168281
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam08916
      Location:2376
      Phe_ZIP; Phenylalanine zipper
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