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    Limk2 LIM motif-containing protein kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 16886, updated on 5-Sep-2021

    Summary

    Official Symbol
    Limk2provided by MGI
    Official Full Name
    LIM motif-containing protein kinase 2provided by MGI
    Primary source
    MGI:MGI:1197517
    See related
    Ensembl:ENSMUSG00000020451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lim; whe; Limk; Limk-2
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.2), colon adult (RPKM 19.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Limk2 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3293297..3359249, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3343297..3409276, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (3243300..3309238, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene predicted gene, 51879 Neighboring gene ring finger protein 185 Neighboring gene RIKEN cDNA 8430429K09 gene Neighboring gene predicted gene, 53661 Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Gene trapped (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 9430059K01, A930024P04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    LIM domain kinase 2
    Names
    LIM kinase 2
    NP_001029202.1
    NP_001348552.1
    NP_034848.1
    NP_774958.1
    XP_006514610.1
    XP_006514611.1
    XP_006514615.1
    XP_030101468.1
    XP_030101469.1
    XP_030101470.1
    XP_030101471.1
    XP_036012254.1
    XP_036012255.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034030.2NP_001029202.1  LIM domain kinase 2 isoform c

      See identical proteins and their annotated locations for NP_001029202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 5' exons, but has an alternate 5' terminal exon, which results in a downstream translation start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AB012291, AK034900
      Consensus CDS
      CCDS24360.1
      UniProtKB/Swiss-Prot
      O54785
      UniProtKB/TrEMBL
      Q8BS94
      Related
      ENSMUSP00000105656.3, ENSMUST00000110029.9
      Conserved Domains (2) summary
      cd14222
      Location:150421
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:149
      PDZ; PDZ domain (Also known as DHR or GLGF)
    2. NM_001361623.1NP_001348552.1  LIM domain kinase 2 isoform d

      Status: VALIDATED

      Source sequence(s)
      AK034900, AL713875, BY289120, CA316117, CV784400
      Consensus CDS
      CCDS88122.1
      Related
      ENSMUSP00000099163.4, ENSMUST00000101640.10
      Conserved Domains (4) summary
      cd09465
      Location:46104
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:316593
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:131215
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1544
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    3. NM_010718.4NP_034848.1  LIM domain kinase 2 isoform a

      See identical proteins and their annotated locations for NP_034848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK034900, AK146099, BY253265
      Consensus CDS
      CCDS24358.1
      UniProtKB/Swiss-Prot
      O54785
      UniProtKB/TrEMBL
      Q8BS94
      Related
      ENSMUSP00000099162.4, ENSMUST00000101638.4
      Conserved Domains (5) summary
      cd09465
      Location:67125
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:334601
      STYKc; Protein kinase; unclassified specificity
      cd14222
      Location:337608
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:152236
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1265
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    4. NM_173053.2NP_774958.1  LIM domain kinase 2 isoform b

      See identical proteins and their annotated locations for NP_774958.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons, but has an alternate 5' terminal exon which includes an alternate translation start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK034900, AK146099, BY289120, CV784400
      Consensus CDS
      CCDS24359.1
      UniProtKB/Swiss-Prot
      O54785
      UniProtKB/TrEMBL
      Q8BS94
      Related
      ENSMUSP00000099165.4, ENSMUST00000101642.10
      Conserved Domains (5) summary
      cd09465
      Location:46104
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      smart00221
      Location:313580
      STYKc; Protein kinase; unclassified specificity
      cd14222
      Location:316587
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:131215
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1544
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3293297..3359249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156361.1XP_036012254.1  LIM domain kinase 2 isoform X4

      Conserved Domains (4) summary
      cd09465
      Location:52110
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:322599
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:137221
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:2450
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. XM_030245609.2XP_030101469.1  LIM domain kinase 2 isoform X6

      Related
      ENSMUST00000134576.8
      Conserved Domains (3) summary
      cd14222
      Location:259536
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      cl02475
      Location:147
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00595
      Location:74158
      PDZ; PDZ domain (Also known as DHR or GLGF)
    3. XM_030245610.2XP_030101470.1  LIM domain kinase 2 isoform X7

      Conserved Domains (3) summary
      cd14222
      Location:259530
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      cl02475
      Location:147
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00595
      Location:74158
      PDZ; PDZ domain (Also known as DHR or GLGF)
    4. XM_036156362.1XP_036012255.1  LIM domain kinase 2 isoform X5

      Conserved Domains (4) summary
      cd09465
      Location:45103
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:315592
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:130214
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:1843
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    5. XM_006514552.5XP_006514615.1  LIM domain kinase 2 isoform X8

      Conserved Domains (2) summary
      cd14222
      Location:150427
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:149
      PDZ; PDZ domain (Also known as DHR or GLGF)
    6. XM_030245611.2XP_030101471.1  LIM domain kinase 2 isoform X9

      Conserved Domains (2) summary
      cd14222
      Location:150421
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      pfam00595
      Location:149
      PDZ; PDZ domain (Also known as DHR or GLGF)
    7. XM_006514548.4XP_006514611.1  LIM domain kinase 2 isoform X3

      Conserved Domains (4) summary
      cd09465
      Location:67125
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:337614
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      cl02475
      Location:1265
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00595
      Location:152236
      PDZ; PDZ domain (Also known as DHR or GLGF)
    8. XM_006514547.2XP_006514610.1  LIM domain kinase 2 isoform X2

      Conserved Domains (4) summary
      cd09465
      Location:125183
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:395666
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      cl02475
      Location:70123
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00595
      Location:210294
      PDZ; PDZ domain (Also known as DHR or GLGF)
    9. XM_030245608.1XP_030101468.1  LIM domain kinase 2 isoform X1

      Conserved Domains (4) summary
      cd09465
      Location:125183
      LIM2_LIMK2; The second LIM domain of LIMK2 (LIM domain Kinase 2)
      cd14222
      Location:395672
      STKc_LIMK2; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2
      cl02475
      Location:70123
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam00595
      Location:210294
      PDZ; PDZ domain (Also known as DHR or GLGF)
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