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    Limk1 LIM-domain containing, protein kinase [ Mus musculus (house mouse) ]

    Gene ID: 16885, updated on 9-Sep-2018

    Summary

    Official Symbol
    Limk1provided by MGI
    Official Full Name
    LIM-domain containing, protein kinaseprovided by MGI
    Primary source
    MGI:MGI:104572
    See related
    Ensembl:ENSMUSG00000029674 Vega:OTTMUSG00000026202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Limk; KIZ-1; LIMK-1
    Summary
    This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.2), whole brain E14.5 (RPKM 14.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Limk1 in Genome Data Viewer
    Location:
    5 74.73 cM; 5 G2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (134656039..134688659, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135131909..135164460, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene linker for activation of T cells family, member 2 Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene predicted gene 10369 Neighboring gene elastin Neighboring gene predicted gene, 30003 Neighboring gene transmembrane protein 270

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of stress fiber assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    LIM domain kinase 1
    NP_001292804.1
    NP_034847.1
    XP_006504459.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305875.1NP_001292804.1  LIM domain kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001292804.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons and contains an alternate 5' terminal exon, resulting in the use of an alternate translation start site, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC166938, AK141813, BQ828670, BX527775, BY230595, CV563459
      Consensus CDS
      CCDS84969.1
      UniProtKB/TrEMBL
      E9PVB6, Q3UR47
      Related
      ENSMUSP00000106864.1, OTTMUSP00000032204, ENSMUST00000111233.7, OTTMUST00000064767
      Conserved Domains (5) summary
      cd09464
      Location:76130
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      smart00219
      Location:334596
      TyrKc; Tyrosine kinase, catalytic domain
      cd14221
      Location:337603
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:157247
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:4369
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. NM_010717.3NP_034847.1  LIM domain kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_034847.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK141813, BQ828670, BX527775, CJ066818, CV563459
      Consensus CDS
      CCDS19724.1
      UniProtKB/Swiss-Prot
      P53668
      UniProtKB/TrEMBL
      Q3UR47
      Related
      ENSMUSP00000015137.3, OTTMUSP00000032203, ENSMUST00000015137.9, OTTMUST00000064766
      Conserved Domains (5) summary
      cd09462
      Location:577
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      cd09464
      Location:84138
      LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
      smart00219
      Location:342604
      TyrKc; Tyrosine kinase, catalytic domain
      cd14221
      Location:345611
      STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
      pfam00595
      Location:165255
      PDZ; PDZ domain (Also known as DHR or GLGF)

    RNA

    1. NR_131247.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC166938, AK141813, BQ828670, BX527775, BY230595, CV563459
      Related
      ENSMUST00000134093.1, OTTMUST00000064769

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      134656039..134688659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504396.3XP_006504459.1  LIM domain kinase 1 isoform X1

      Conserved Domains (4) summary
      cd09462
      Location:577
      LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
      pfam00595
      Location:165255
      PDZ; PDZ domain (Also known as DHR or GLGF)
      cl02475
      Location:84138
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl21453
      Location:345470
      PKc_like; Protein Kinases, catalytic domain
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