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    Lif leukemia inhibitory factor [ Mus musculus (house mouse) ]

    Gene ID: 16878, updated on 24-Jul-2018

    Summary

    Official Symbol
    Lifprovided by MGI
    Official Full Name
    leukemia inhibitory factorprovided by MGI
    Primary source
    MGI:MGI:96787
    See related
    Ensembl:ENSMUSG00000034394 Vega:OTTMUSG00000005061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See Lif in Genome Data Viewer
    Location:
    11 A1; 11 2.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (4257568..4272514)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4157571..4172517)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11956 Neighboring gene oncostatin M Neighboring gene predicted gene 11959 Neighboring gene predicted gene 11958

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
      ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
    • IL-6-type cytokine receptor ligand interactions, organism-specific biosystem (from REACTOME)
      IL-6-type cytokine receptor ligand interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-6 family signaling, organism-specific biosystem (from REACTOME)
      Interleukin-6 family signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    growth factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    leukemia inhibitory factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukemia inhibitory factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    decidualization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    decidualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    leukemia inhibitory factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukemia inhibitory factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung lobe morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung vasculature development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    maternal process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of astrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of histone H3-K27 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of metanephric nephron tubule epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    spongiotrophoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stem cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transdifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    trophoblast giant cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    leukemia inhibitory factor
    Names
    d factor
    differentiation-stimulating factor
    myeloid leukaemia inhibitory factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039537.2NP_001034626.1  leukemia inhibitory factor isoform b

      See identical proteins and their annotated locations for NP_001034626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL731658, BP765086, BY233044, X06381
      Consensus CDS
      CCDS24384.1
      UniProtKB/Swiss-Prot
      P09056
      UniProtKB/TrEMBL
      F8WH42
      Related
      ENSMUSP00000036853.3, ENSMUST00000040750.3
      Conserved Domains (1) summary
      smart00080
      Location:1147
      LIF_OSM; leukemia inhibitory factor
    2. NM_008501.2NP_032527.1  leukemia inhibitory factor isoform a precursor

      See identical proteins and their annotated locations for NP_032527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK042018, AL731658, BY207460
      Consensus CDS
      CCDS24383.1
      UniProtKB/Swiss-Prot
      P09056
      Related
      ENSMUSP00000067066.5, OTTMUSP00000005253, ENSMUST00000066283.11, OTTMUST00000011278
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      4257568..4272514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514544.3XP_006514607.1  leukemia inhibitory factor isoform X2

      See identical proteins and their annotated locations for XP_006514607.1

      UniProtKB/TrEMBL
      F8WH42
      Conserved Domains (1) summary
      smart00080
      Location:1147
      LIF_OSM; leukemia inhibitory factor
    2. XM_006514543.3XP_006514606.1  leukemia inhibitory factor isoform X1

      See identical proteins and their annotated locations for XP_006514606.1

      UniProtKB/Swiss-Prot
      P09056
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor
    3. XM_006514542.3XP_006514605.1  leukemia inhibitory factor isoform X1

      See identical proteins and their annotated locations for XP_006514605.1

      UniProtKB/Swiss-Prot
      P09056
      Conserved Domains (1) summary
      smart00080
      Location:35192
      LIF_OSM; leukemia inhibitory factor
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