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    Lamp2 lysosomal-associated membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 16784, updated on 14-Sep-2021

    Summary

    Official Symbol
    Lamp2provided by MGI
    Official Full Name
    lysosomal-associated membrane protein 2provided by MGI
    Primary source
    MGI:MGI:96748
    See related
    Ensembl:ENSMUSG00000016534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lam; Mac; Lamp; Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
    Expression
    Ubiquitous expression in kidney adult (RPKM 53.2), placenta adult (RPKM 47.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Lamp2 in Genome Data Viewer
    Location:
    X A3.3; X 22.67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37488524..37545337, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38399647..38456460, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (35758241..35809632, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 40 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene predicted gene, 51613 Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein targeting to lysosome involved in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in autolysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of chaperone-mediated autophagy translocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in platelet dense granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysosome-associated membrane glycoprotein 2
    Names
    CD107 antigen-like family member B
    lysosomal membrane glycoprotein 2
    lysosomal membrane glycoprotein type B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017959.2NP_001017959.1  lysosome-associated membrane glycoprotein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001017959.1

      Status: VALIDATED

      Source sequence(s)
      AK159272, AK163933, AL513356
      Consensus CDS
      CCDS30092.1
      UniProtKB/Swiss-Prot
      P17047
      Related
      ENSMUSP00000016678.8, ENSMUST00000016678.14
      Conserved Domains (1) summary
      pfam01299
      Location:106415
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    2. NM_001290485.2NP_001277414.1  lysosome-associated membrane glycoprotein 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277414.1

      Status: VALIDATED

      Source sequence(s)
      AK078193, AK163933, AL513356, BQ176100
      Consensus CDS
      CCDS72369.1
      UniProtKB/Swiss-Prot
      P17047
      UniProtKB/TrEMBL
      Q8C5K0
      Related
      ENSMUSP00000074448.6, ENSMUST00000074913.12
      Conserved Domains (1) summary
      pfam01299
      Location:106416
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    3. NM_010685.4NP_034815.2  lysosome-associated membrane glycoprotein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034815.2

      Status: VALIDATED

      Source sequence(s)
      AK080234, AK163933, AL513356
      Consensus CDS
      CCDS30093.1
      UniProtKB/Swiss-Prot
      P17047
      Related
      ENSMUSP00000052283.9, ENSMUST00000061755.9
      Conserved Domains (1) summary
      pfam01299
      Location:106415
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RNA

    1. NR_152733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL513356

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37488524..37545337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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