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    Lamp2 lysosomal-associated membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 16784, updated on 21-Oct-2018

    Summary

    Official Symbol
    Lamp2provided by MGI
    Official Full Name
    lysosomal-associated membrane protein 2provided by MGI
    Primary source
    MGI:MGI:96748
    See related
    Ensembl:ENSMUSG00000016534 Vega:OTTMUSG00000017230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c
    Expression
    Ubiquitous expression in kidney adult (RPKM 53.2), placenta adult (RPKM 47.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See Lamp2 in Genome Data Viewer
    Location:
    X A3.3; X 22.67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (38401357..38456463, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (35758241..35809632, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 40 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene Neighboring gene coiled-coil domain containing 94 pseudogene Neighboring gene predicted gene 9488

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone-mediated autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to lysosome involved in chaperone-mediated autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to lysosome involved in chaperone-mediated autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    autolysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chaperone-mediated autophagy translocation complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal matrix ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    platelet dense granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysosome-associated membrane glycoprotein 2
    Names
    CD107 antigen-like family member B
    lysosomal membrane glycoprotein 2
    lysosomal membrane glycoprotein type B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017959.2NP_001017959.1  lysosome-associated membrane glycoprotein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001017959.1

      Status: VALIDATED

      Source sequence(s)
      AK159272, AK163933, AL513356
      Consensus CDS
      CCDS30092.1
      UniProtKB/Swiss-Prot
      P17047
      Related
      ENSMUSP00000016678.7, OTTMUSP00000018801, ENSMUST00000016678.13, OTTMUST00000041813
      Conserved Domains (1) summary
      pfam01299
      Location:106415
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    2. NM_001290485.2NP_001277414.1  lysosome-associated membrane glycoprotein 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277414.1

      Status: VALIDATED

      Source sequence(s)
      AK078193, AK163933, AL513356, BQ176100
      Consensus CDS
      CCDS72369.1
      UniProtKB/Swiss-Prot
      P17047
      UniProtKB/TrEMBL
      Q8C5K0
      Related
      ENSMUSP00000074448.5, OTTMUSP00000018802, ENSMUST00000074913.11
      Conserved Domains (1) summary
      pfam01299
      Location:106416
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    3. NM_010685.4NP_034815.2  lysosome-associated membrane glycoprotein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034815.2

      Status: VALIDATED

      Source sequence(s)
      AK080234, AK163933, AL513356
      Consensus CDS
      CCDS30093.1
      UniProtKB/Swiss-Prot
      P17047
      Related
      ENSMUSP00000052283.8, OTTMUSP00000018739, ENSMUST00000061755.8, OTTMUST00000041711
      Conserved Domains (1) summary
      pfam01299
      Location:106415
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)

    RNA

    1. NR_152733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL513356

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      38401357..38456463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001782739.1 RNA Sequence

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