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    Lamb1 laminin B1 [ Mus musculus (house mouse) ]

    Gene ID: 16777, updated on 7-Sep-2021

    Summary

    Official Symbol
    Lamb1provided by MGI
    Official Full Name
    laminin B1provided by MGI
    Primary source
    MGI:MGI:96743
    See related
    Ensembl:ENSMUSG00000002900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lamb; C77966; C80098; C81607; Lamb-1; Lamb1-1; D130003D08Rik
    Expression
    Broad expression in ovary adult (RPKM 32.7), placenta adult (RPKM 32.3) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Lamb1 in Genome Data Viewer
    Location:
    12 A2; 12 13.39 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31315230..31379643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31265146..31329644)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (31950159..32014504)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6993 Neighboring gene predicted gene, 32899 Neighboring gene predicted gene, 24613 Neighboring gene dihydrolipoamide dehydrogenase Neighboring gene tripartite motif-containing 13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables extracellular matrix structural constituent ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables glycosphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in basement membrane assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuronal-glial interaction involved in cerebral cortex radial glia guided migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of laminin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin-10 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of laminin-10 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin-2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin-8 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit beta-1
    Names
    laminin B1 chain
    laminin B1 subunit 1
    laminin-1 subunit beta
    laminin-10 subunit beta
    laminin-111
    laminin-12 subunit beta
    laminin-2 subunit beta
    laminin-6 subunit beta
    laminin-8 subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008482.3NP_032508.3  laminin subunit beta-1 precursor

      Status: VALIDATED

      Source sequence(s)
      CR974423, CT571245
      Consensus CDS
      CCDS25862.2
      Related
      ENSMUSP00000002979.10, ENSMUST00000002979.16
      Conserved Domains (6) summary
      pfam05483
      Location:12011667
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00180
      Location:773818
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:509548
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:14561776
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:821869
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:44269
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      31315230..31379643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514993.2XP_006515056.1  laminin subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006515056.1

      UniProtKB/Swiss-Prot
      P02469
      Related
      ENSMUSP00000132778.2, ENSMUST00000169088.8
      Conserved Domains (6) summary
      pfam05483
      Location:12011667
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00180
      Location:773818
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:509548
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      TIGR02168
      Location:14561776
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00053
      Location:821869
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:44269
      Laminin_N; Laminin N-terminal (Domain VI)
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