U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CDC20B cell division cycle 20B [ Homo sapiens (human) ]

    Gene ID: 166979, updated on 17-Jun-2024

    Summary

    Official Symbol
    CDC20Bprovided by HGNC
    Official Full Name
    cell division cycle 20Bprovided by HGNC
    Primary source
    HGNC:HGNC:24222
    See related
    Ensembl:ENSG00000164287 MIM:620335; AllianceGenome:HGNC:24222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6VTS76519
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to be part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDC20B in Genome Data Viewer
    Location:
    5q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (55112971..55173177, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (55940297..56000463, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (54408799..54469005, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene granzyme A pseudogene 1 Neighboring gene granzyme A Neighboring gene Sharpr-MPRA regulatory region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16009 Neighboring gene glutathione peroxidase 8 (putative) Neighboring gene microRNA 449a Neighboring gene microRNA 449b Neighboring gene microRNA 449c Neighboring gene MPRA-validated peak5244 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22551 Neighboring gene Sharpr-MPRA regulatory region 9706 Neighboring gene uncharacterized LOC124900978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54527615-54528254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:54528255-54528894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16013 Neighboring gene Sharpr-MPRA regulatory region 6084 Neighboring gene multiciliate differentiation and DNA synthesis associated cell cycle protein Neighboring gene cyclin O

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37927

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in deuterosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division cycle protein 20 homolog B
    Names
    CDC20 cell division cycle 20 homolog B
    CDC20-like protein
    cell division cycle 20 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145734.2NP_001139206.2  cell division cycle protein 20 homolog B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 2, which is shorter than isoform 3.
      Source sequence(s)
      AB086378, AC091977, AK095246, DB237622
      Consensus CDS
      CCDS47207.1
      UniProtKB/Swiss-Prot
      Q86Y33
      Related
      ENSP00000315720.6, ENST00000322374.10
      Conserved Domains (3) summary
      COG2319
      Location:183476
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:277313
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:236475
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001170402.1NP_001163873.1  cell division cycle protein 20 homolog B isoform 3

      See identical proteins and their annotated locations for NP_001163873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC091977, AK095246, BC136572, DB237622
      Consensus CDS
      CCDS54852.1
      UniProtKB/Swiss-Prot
      B7WNV8, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q86Y33, Q8IUZ8, Q8N1S1, Q8NG56
      Related
      ENSP00000370781.2, ENST00000381375.7
      Conserved Domains (3) summary
      COG2319
      Location:230518
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:276313
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:276517
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_152623.2NP_689836.2  cell division cycle protein 20 homolog B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.
      Source sequence(s)
      AC091977, AI471861, AK095246, DB237622
      Consensus CDS
      CCDS3966.1
      UniProtKB/Swiss-Prot
      Q86Y33
      Related
      ENSP00000296733.1, ENST00000296733.5
      Conserved Domains (3) summary
      COG2319
      Location:230514
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:276313
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:276513
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      55112971..55173177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      55940297..56000463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)