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    Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

    Gene ID: 16653, updated on 12-Mar-2019

    Summary

    Official Symbol
    Krasprovided by MGI
    Official Full Name
    Kirsten rat sarcoma viral oncogene homologprovided by MGI
    Primary source
    MGI:MGI:96680
    See related
    Ensembl:ENSMUSG00000030265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; AI929937; c-Ki-ras
    Expression
    Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
    Orthologs

    Genomic context

    See Kras in Genome Data Viewer
    Location:
    6 G3; 6 77.37 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (145216699..145250291, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (145165219..145198751, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene cancer susceptibility candidate 1 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7141

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    LRR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    endocrine signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain astrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Rac protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    visual learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GTPase KRas
    Names
    Kirsten rat sarcoma oncogene 2, expressed
    p21 protein
    v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021284.6NP_067259.4  GTPase KRas

      See identical proteins and their annotated locations for NP_067259.4

      Status: VALIDATED

      Source sequence(s)
      AC157091, AK164065
      Consensus CDS
      CCDS20693.1
      UniProtKB/Swiss-Prot
      P32883
      UniProtKB/TrEMBL
      Q5J7N1
      Related
      ENSMUSP00000032399.5, ENSMUST00000032399.11
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00010
      Location:16166
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      145216699..145250291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506919.3XP_006506982.1  GTPase KRas isoform X2

      See identical proteins and their annotated locations for XP_006506982.1

      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases
    2. XM_006506918.3XP_006506981.1  GTPase KRas isoform X1

      See identical proteins and their annotated locations for XP_006506981.1

      UniProtKB/Swiss-Prot
      P32883
      UniProtKB/TrEMBL
      Q0VDV7
      Related
      ENSMUSP00000107339.1, ENSMUST00000111710.7
      Conserved Domains (1) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_166305.2 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1734813..1768417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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