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    Kpna6 karyopherin (importin) alpha 6 [ Mus musculus (house mouse) ]

    Gene ID: 16650, updated on 16-Oct-2021

    Summary

    Official Symbol
    Kpna6provided by MGI
    Official Full Name
    karyopherin (importin) alpha 6provided by MGI
    Primary source
    MGI:MGI:1100836
    See related
    Ensembl:ENSMUSG00000003731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IPOA7; Kpna5; NPI-2
    Expression
    Ubiquitous expression in testis adult (RPKM 30.4), subcutaneous fat pad adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kpna6 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129537772..129566560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129643979..129672767, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129321223..129350011, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene taxilin alpha Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within maternal process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitigation of host defenses by symbiont IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of viral life cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    importin subunit alpha-7
    Names
    importin alpha 7
    importin alpha-S2
    karyopherin (importin) alpha 5
    karyopherin subunit alpha-6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008468.4NP_032494.3  importin subunit alpha-7

      See identical proteins and their annotated locations for NP_032494.3

      Status: VALIDATED

      Source sequence(s)
      AK046371, AL671759, CJ082540
      Consensus CDS
      CCDS18701.1
      UniProtKB/Swiss-Prot
      O35345
      UniProtKB/TrEMBL
      Q8BH30
      Related
      ENSMUSP00000099650.5, ENSMUST00000102590.11
      Conserved Domains (5) summary
      COG5064
      Location:36525
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:251365
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9102
      IBB; Importin beta binding domain
      pfam16186
      Location:464508
      Arm_3; Atypical Arm repeat
      sd00043
      Location:254279
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129537772..129566560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502814.4XP_006502877.1  importin subunit alpha-7 isoform X1

      See identical proteins and their annotated locations for XP_006502877.1

      Related
      ENSMUSP00000003828.5, ENSMUST00000003828.11
      Conserved Domains (2) summary
      COG5064
      Location:41530
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:259284
      ARM; armadillo repeat [structural motif]
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