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    Kpna2 karyopherin subunit alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16647, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kpna2provided by MGI
    Official Full Name
    karyopherin subunit alpha 2provided by MGI
    Primary source
    MGI:MGI:103561
    See related
    Ensembl:ENSMUSG00000018362 AllianceGenome:MGI:103561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rch1; IPOA1; PTAC58; 2410044B12Rik
    Summary
    Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 144.8), liver E14 (RPKM 99.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Kpna2 in Genome Data Viewer
    Location:
    11 E1; 11 70.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106879455..106890351, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106988629..106999525, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene STARR-positive B cell enhancer ABC_E11496 Neighboring gene STARR-positive B cell enhancer ABC_E8465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106822918-106823220 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3031 Neighboring gene STARR-positive B cell enhancer ABC_E4007 Neighboring gene predicted gene, 39424 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC91246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    importin subunit alpha-1
    Names
    RAG cohort protein 1
    SRP1-alpha
    importin alpha 1
    importin alpha P1
    importin subunit alpha-2
    karyopherin (importin) alpha 2
    m-importin-alpha-P1
    pendulin
    pore targeting complex 58 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010655.3NP_034785.1  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_034785.1

      Status: VALIDATED

      Source sequence(s)
      AI664586, AK075952, BC086789
      Consensus CDS
      CCDS25565.1
      UniProtKB/Swiss-Prot
      P52293, Q64292
      UniProtKB/TrEMBL
      Q52L97, Q641N9
      Related
      ENSMUSP00000018506.7, ENSMUST00000018506.13
      Conserved Domains (6) summary
      COG5064
      Location:9528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:113238
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:1098
      IBB; Importin beta binding domain
      pfam16186
      Location:458508
      Arm_3; Atypical Arm repeat
      sd00044
      Location:457494
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:115147
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106879455..106890351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)