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    Kpna2 karyopherin (importin) alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 16647, updated on 12-Aug-2018

    Summary

    Official Symbol
    Kpna2provided by MGI
    Official Full Name
    karyopherin (importin) alpha 2provided by MGI
    Primary source
    MGI:MGI:103561
    See related
    Ensembl:ENSMUSG00000018362 Vega:OTTMUSG00000003580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rch1; IPOA1; PTAC58; 2410044B12Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 144.8), liver E14 (RPKM 99.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See Kpna2 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (106988629..106999525, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (106849943..106860839, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCG) Neighboring gene predicted gene, 39424

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91246

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    importin subunit alpha-1
    Names
    RAG cohort protein 1
    SRP1-alpha
    importin alpha 1
    importin alpha P1
    importin subunit alpha-2
    karyopherin subunit alpha-2
    m-importin-alpha-P1
    pendulin
    pore targeting complex 58 kDa subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010655.3NP_034785.1  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_034785.1

      Status: VALIDATED

      Source sequence(s)
      AI664586, AK075952, BC086789
      Consensus CDS
      CCDS25565.1
      UniProtKB/Swiss-Prot
      P52293
      UniProtKB/TrEMBL
      Q52L97
      Related
      ENSMUSP00000018506.6, OTTMUSP00000003739, ENSMUST00000018506.12, OTTMUST00000007708
      Conserved Domains (6) summary
      COG5064
      Location:9528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:113238
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:1098
      IBB; Importin beta binding domain
      pfam16186
      Location:458508
      Arm_3; Atypical Arm repeat
      sd00044
      Location:457494
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:115147
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      106988629..106999525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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