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    Fabp5 fatty acid binding protein 5, epidermal [ Mus musculus (house mouse) ]

    Gene ID: 16592, updated on 6-Sep-2021

    Summary

    Official Symbol
    Fabp5provided by MGI
    Official Full Name
    fatty acid binding protein 5, epidermalprovided by MGI
    Primary source
    MGI:MGI:101790
    See related
    Ensembl:ENSMUSG00000027533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kl; ma; Klbp; mal1; Fabpe; E-FABP; PA-FABP
    Summary
    The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. In humans this gene has been associated with psoriasis and type 2 diabetes. In mouse deficiency of this gene in combination with a deficiency in Fabp4 confers protection against atherosclerosis, diet-induced obesity, insulin resistance and experimental autoimmune encephalomyelitis (the mouse model for multiple sclerosis). Alternative splicing results in multiple transcript variants that encode different protein isoforms. The mouse genome contains many pseudogenes similar to this locus. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in liver E18 (RPKM 937.5), liver E14 (RPKM 371.8) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Fabp5 in Genome Data Viewer
    Location:
    3; 3 A1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10077645..10081670)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10012585..10016610)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (10012606..10016610)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene EST AA881470 pseudogene Neighboring gene predicted gene, 33365 Neighboring gene myelin expression factor 2 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fatty acid-binding protein 5; uncharacterized protein LOC16592
    Names
    epidermal-type fatty acid-binding protein
    epithelial fatty acid-binding protein
    fatty acid-binding protein, epidermal
    keratinocyte lipid-binding protein
    psoriasis-associated fatty acid-binding protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272097.1NP_001259026.1  fatty acid-binding protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (by one amino acid; isoform 2), compared to isoform 1.
      Source sequence(s)
      AC157379
      Conserved Domains (1) summary
      pfam00061
      Location:9111
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    2. NM_001272098.1NP_001259027.1  uncharacterized protein LOC16592 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. Variant 3 lacks a large portion of the central coding region found in variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform lacks the lipocalin domain found in isoform 1.
      Source sequence(s)
      AC157379, BE987062, W54445
      Conserved Domains (1) summary
      cl10502
      Location:626
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    3. NM_010634.3NP_034764.1  fatty acid-binding protein 5 isoform 1

      See identical proteins and their annotated locations for NP_034764.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC157379, AK011551, BE987062
      Consensus CDS
      CCDS38388.1
      UniProtKB/Swiss-Prot
      Q05816
      UniProtKB/TrEMBL
      Q497I3
      Related
      ENSMUSP00000029046.9, ENSMUST00000029046.9
      Conserved Domains (1) summary
      pfam00061
      Location:9134
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      10077645..10081670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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